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- Table of Contents
1 Citations 7 Q&As
1 Citations 9 Q&As
Facts about Interleukin-6 receptor subunit beta.
Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). This causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003).
Human | |
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Gene Name: | IL6ST |
Uniprot: | P40189 |
Entrez: | 3572 |
Belongs to: |
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type I cytokine receptor family |
CD130 antigen; CD130; CDw130; DKFZp564F053; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6RB; IL-6R-beta; IL6ST; interleukin 6 signal transducer (gp130, oncostatin M receptor); interleukin receptor beta chain; interleukin-6 receptor subunit beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; membrane glycoprotein gp130; Oncostatin-M receptor subunit alpha
Mass (kDA):
103.537 kDA
Human | |
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Location: | 5q11.2 |
Sequence: | 5; NC_000005.10 (55935095..55994963, complement) |
Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). Expressed in blood serum (at protein level) (PubMed:24629561).
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
PMID: 2261637 by Hibi M., et al. Molecular cloning and expression of an IL-6 signal transducer, gp130.
PMID: 10880057 by Tanaka M., et al. Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis.
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