IL3RA Antibodies

Interleukin-3 receptor subunit alpha (IL3RA)

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Gene Information

Human
Gene Name:	IL3RA
Uniprot:	P26951
Entrez:	3563

Family

Belongs to:
type I cytokine receptor family

Alternative Names

CD123 antigen; CD123; hIL3Ra; hIL-3Ra; IL-3 R alpha; IL-3 receptor subunit alpha; IL3R alpha; IL-3R alpha; IL-3R subunit alpha; IL3R; IL3RA; IL-3Ra; IL-3R-alpha; IL3RAY; IL3RX; IL3RY; interleukin 3 receptor, alpha (low affinity); interleukin-3 receptor subunit alpha; MGC34174

Molecular Weight

Mass (kDA):
43.33 kDA

Genomic Context

Human
Location:	Xp22.33 and Yp11.2
Sequence:	X|Y; NC_000023.11 (1336574..1382689)

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

• Leukemia
• Neoplasms
• Myeloid Leukemia
• Leukemia, Myelocytic, Acute
• Lymphoma
• Malignant Neoplasms
• Skin Neoplasms
• Hiv Infections
• Malignant Paraganglionic Neoplasm
• Immunologic Deficiency Syndromes
• Hematologic Neoplasms
• Lymphoid Leukemia

• Acute Leukemia
• Carcinoma
• Lymphoma, Non-hodgkin
• Infective Disorder
• Sclerosis
• Dermatologic Disorders
• Chronic Lymphocytic Leukemia

Pathways

• Immune Response
• Pathogenesis
• Secretion
• Cell Differentiation
• Cell Proliferation
• Cell Cycle
• Endocytosis
• Localization
• Cytokine Production
• Inflammatory Response
• Innate Immune Response
• Regeneration
• Cell Growth

• Dendritic Cell Proliferation
• Cell Adhesion
• T Cell Selection
• Transposition
• Cell Migration
• Osteoblast Differentiation
• Cytokine Secretion

PTMs

• Phosphorylation

• Methylation

• Acetylation

Research Areas

• Cytokine Research
• Phospho-Specific

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL3RA

Best Uses Of The IL3RA Marker

A high-affinity prim antibody can be a valuable tool in your research. Steven Boster stocks high-affinity antibodies, which are frequently cited by scientists. These antibodies are trusted by the research community because they have been validated using methods such as Western Blotting, Immunohistochemistry, and ELISA. This highly-rated product is described in detail below.

Primary antibodies with high affinity

We used a cloning technique to identify IL3RA expressing cells. This procedure purifies single B cells from human PBMC. We stained single cells for 30 minutes with different antibodies including PD-1-BB515, CD20-Pacific Blue, IgD-PerCP-Cy5.5, and CXCR5-PE-Dazzle 594. After washing the cells twice, the single B cells were counted. The single cells were then counted.

IL3RA is a member in the IL3RA superfamily. Its cDNA can be encoded by the CD123 genes. These two genes have overlapping genomic structures and are probably related. Although they may have a common ancestor their chromosomes are different. The IL3RA genes are different from the ILR5A genes, which have one copy on each chromosome.

IL3RA/CD123 can be produced by activated T and mast cells. It is a pleiotropic cytokine. It stimulates hemopoietic cell proliferation and differentiation. Its binding to receptor complexes is what mediates the biological effects of IL-3. The high-affinity IL3RA/CD123 marker is composed of two subunits - alpha and beta.

Atlas Prestige Antibodies are derived from the Human Protein Atlas Project. This project identifies proteins in humans with high-affinity, ELISAs. These antibodies have been tested on hundreds if normal and diseased tissues. These antibodies have been subject to immunofluorescence analysis. Furthermore, they have mapped the human proteome at a subcellular level. The Human Protein Atlas project site provides characterization protocols for Prestige Antibodies.

The evolution of anti-spike B cell clones in humans after vaccination is described in multiple reports. Multiple reports describe the increase in circulating MBCs after SARS-CoV-2 vaccine mRNA vaccination. However, anti-spike antibody avidity was significantly higher over the course the study. High-affinity primary antibodies against the IL3RA marker in the blood correlated with increased avidity and neutralization capacity.

IL3RA plays a key role in activating the immune response. It is involved in the pathogenesis and progression of HSV. It is expressed by peripheral blood mononuclear cells and fibroblasts. These cells express IL3RA and activate MBCs and chemokines. They also influence differentiation and growth of adipocytes.

IL3RA

The IL3RA RNA gene encodes a key signaling component of many interleukins receptors. These include interleukin-2 (-4), -7, -7, and IL-15. It is a powerful way of studying a wide range of biological processes by using the IL3RA marker gene. Boster's high-affinity primary antibodies are trusted by the scientific community for their robust performance.