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IL1RAP Antibodies
AND IL1RAP ELISA kits, IL1RAP Proteins
Many biological assays use antibodies to detect IL1RAP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IL1RAP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IL1RAP antibodies...
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IL1RAP Infographic by Boster Bio
All IL1RAP Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK1769
96 wells/kit, with removable strips.
Cat # EK1769
96 wells/kit, with removable strips.
IL1RAP Overview
Facts about Interleukin-1 receptor accessory protein.
Interleukin-1 receptor accessory protein (IL1RAP)
Coreceptor for IL1RL2 from the IL-36 signaling system (By similarity). Coreceptor with IL1R1 from the IL-1 signaling system.
Associates with IL1R1 jumped to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1- dependent activation of NF-kappa-B and other pathways. Signaling requires the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of their receptor/coreceptor subunits.
Gene Information
| Human | |
|---|---|
| Gene Name: | IL1RAP |
| Uniprot: | Q9NPH3 |
| Entrez: | 3556 |
Family
| Belongs to: |
|---|
| interleukin-1 receptor family |
Alternative Names
C3orf13IL-1RAcPIL1R3Interleukin-1 receptor 3; FLJ37788; IL-1 R3; IL-1 RAcP; IL-1 receptor accessory protein; IL-1R3; IL-1R-3; IL1RAcP; IL-1RAcP; IL1RAP; interleukin 1 receptor accessory protein; interleukin-1 receptor accessory protein beta; interleukin-1 receptor accessory protein
Molecular Weight
Mass (kDA):
65.418 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q28 |
| Sequence: | 3; NC_000003.12 (190514085..190659750) |
Tissue Specificity
Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia (AML). Overexpressed in patients with chronic obstructive pulmonary disease (COPD). Expressed in T- helper 1 (Th1) and T-helper 2 (Th2) cell subsets (PubMed:10653850).
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.
Diseases
- Inflammation
- Liver Carcinoma
- Hepatitis
- Infective Disorder
- Diabetes Mellitus
- Neoplasms
- Arthritis
- Liver Cirrhosis
- Hepatitis, Chronic
- Myeloid Leukemia
- Physiological Stress
- Diabetes Mellitus, Insulin-dependent
Pathways
- Immune Response
- Pathogenesis
- Cell Proliferation
- Cytokine Production
- Secretion
- Inflammatory Response
- Innate Immune Response
- Cell Differentiation
- Localization
- Cell Death
- Cell Activation
- Interferon-gamma Production
- Chondrocyte Differentiation
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL1RAP
bosterbio.com/bosterbio-gene-info-cards/IL1RAP
References
PMID: 9371760 by Huang J., et al. Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein.
PMID: 10799889 by Jensen L.E., et al. IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein.