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- Table of Contents
Facts about Interleukin-1 receptor type 2.
Non-signaling receptor for IL1A, IL1B and IL1RN.
Reduces IL1B activities.Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also governs cellular response through non-signaling association with IL1RAP after binding to IL1B.
Human | |
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Gene Name: | IL1R2 |
Uniprot: | P27930 |
Entrez: | 7850 |
Belongs to: |
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interleukin-1 receptor family |
beta; CD121b antigen; CD121b; IL-1 R beta; IL-1 RII; IL1R2; IL1RBCD121 antigen-like family member B; IL-1R-beta; IL1RII; IL-1RII; IL-1RT2; IL-1RT-2; interleukin 1 receptor, type II; Interleukin-1 receptor beta; MGC47725
Mass (kDA):
45.421 kDA
Human | |
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Location: | 2q11.2 |
Sequence: | 2; NC_000002.12 (101991805..102028544) |
[Isoform Short]: Secreted.; [Isoform Long]: Cell membrane; Single-pass type I membrane protein.
PMID: 1833184 by McMahan C.J., et al. A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.
PMID: 8702856 by Liu C., et al. Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA.