IL1R1 Antibodies

Interleukin-1 receptor type 1 (IL1R1)

Receptor for IL1A, IL1B and IL1RN.

After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways.

Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

Gene Information

Human
Gene Name:	IL1R1
Uniprot:	P14778
Entrez:	3554

Family

Belongs to:
interleukin-1 receptor family

Alternative Names

CD121 antigen-like family member A; CD121a antigen; CD121a; IL-1 RI; IL1R; IL1R1; IL1RI; IL-1RI; IL1RT1; IL-1RT1; IL-1RT-1; Interleukin 1 Receptor 1; interleukin 1 receptor, type I; interleukin receptor 1; interleukin-1 receptor type 1; p80

Molecular Weight

Mass (kDA):
65.402 kDA

Genomic Context

Human
Location:	2q11.2-q12.1
Sequence:	2; NC_000002.12 (102069638..102179874)

Tissue Specificity

Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells.

Subcellular Localizations

Membrane; Single-pass type I membrane protein. Cell membrane. Secreted.

Diseases

• Inflammation
• Malignant Neoplasms
• Endometrial Polyp
• Degenerative Polyarthritis
• Inflammatory Response
• Neoplasms
• Diabetes Mellitus
• Diabetes Mellitus, Insulin-dependent
• Obesity
• Endometriosis, Site Unspecified
• Communicable Diseases
• Carcinoma
• Edema

• Innate Immune Response
• Nervousness
• Immunologic Deficiency Syndromes
• Dysequilibrium Syndrome
• Escherichia Coli Infections
• Variable Number Tandem Repeat
• Hyperplasia

Interacting Proteins

• PDGFRB
• TRAF6

Pathways

• Pathogenesis
• Secretion
• Inflammatory Response
• Immune Response
• Cell Proliferation
• Cytokine Production
• Cell Death
• Cell Growth
• Cell Activation
• Fertilization
• Proteolysis
• Chemotaxis
• Localization

• Osteoclast Differentiation
• Cell Migration
• Cytokine Secretion
• Neurogenesis
• Skin Development
• Oxidative Phosphorylation
• Antimicrobial Peptide Production

PTMs

• Cleavage
• Phosphorylation

• Ubiquitination
• Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL1R1

Best Uses Of The IL1R1 Marker

If you're looking for information on IL1R1 molecule and Boster Bio, then you've come to the right spot. This article will explain the Boster Bio IL1R1 ELISA kit and the most common IL1RN-like molecule. This product has been used in biomedical research in a variety of applications, including immunoassay.

Boster Bio

The cytokine IL1R1 is also known as IL1RN and is found in a variety cells in humans. It is involved in coronavirus Biology. This cytokine has antiviral and immunomodulatory capabilities and plays an important part in immune reactions. Boster Bio has developed an ELISA platform called PicoKine that uses proprietary trade secrets to allow researchers to analyze samples in a variety of ways.

The IL1R1 gene is a common marker protein that is found in many tissues, organs, and parts of the body. Boster Bio has created antibodies to detect IL1R1 in the body. The antibodies can be monoclonal or multiclonal and react to samples from a variety of animal species. These antibodies block the activity of interleukin-1. This cytokine can be used for monitoring the immune system and other diseases.

IL1R1

Antibodies for IL1R1 target interleukin-1 receptor gene (IL1R1) genes. It is also known under the CD121a and CD121-like family member A names. This gene cluster is located at chromosome 2q12. This marker is involved in cytokine-induced immune and inflammatory responses. Several suppliers offer antisera to this marker.

The cytokine-receptor protein is encoded in the IL1R1 genome. It belongs to the interleukin 1 receptive family. Boster has an antibody catalog that includes the IL1R1 identifier. The company offers high-affinity primary antibodies and controls for Western blotting, Immunohistochemistry, and ELISA. Boster antibodies are available to researchers all over the world.

Anti-IL1R1 antibodies

In vitro experiments were performed using anti-IL1R1 antibody from Boster BIO and Ebiosciences. Both companies produce monoclonal antibody for human IL-1Rs. In our studies, we used antibodies that were both for human and mouse immune systems. We used both monoclonal antibody against mouse IL-1 and human IL-1 cells. Our experiments used mouse immune cells for the purpose of in vitro IL-1R1 studies.

We use transgenic mice HuMabMouses and XenoMouses to generate these antibodies. Both strains are able to express the human immunoglobulin gene loci. This allows us to produce human antibodies with nearly complete immunogenicity. Boster scientists may submit results from their experiments to earn product credits. Their submissions will be accepted all over the world. Our AntiIL1R1 antibodies are extremely useful for research in inflammatory disease.

Boster Bio Anti-IL1RI mAb is used in ELISA, IHC, and WB. It reacts well with Human and can be stored at -20°C. Boster Bio recommends that you also purchase a blocking peptide along with IL1R1 antibody. The peptide is useful in preventing antibody binding with IL-1R1 molecule.

Moreover, nAbs are useful for gene profiling. The expression levels of both antibodies correlated with their co-expression network. Interestingly, the expression levels of two genes in one mouse were correlated with the corresponding T and B-cells. The two genes have different functions on the immune system. The two nAbs also have a similar effect on the production IL-17A. However, their levels were not distinguishable.

We were also able examine the effects HKGT had on IL-1b in a mouse model with AIDS. To determine the effect of HKGT upon the expression of IL-1b in mice, we used a MyD88/Treg axis. We also found that MOILs with age-related supernats expressed higher levels of pro-inflammatory cytokines (IL-6, TNFa, IFN-g).

IL1RN-like protein molecule

Boster Bio's IL1RNlike protein molecule from Boster Bio also inhibits IL-1B. It also has high affinity for IL-1b. Both IL-1a (and IL-1b) are inflammatory mediators that target cells. The IL1RN protein molecule, which is a IL1RN like protein molecule, is designed to inhibit IL-1b through interaction with its receptor. Its unique structure makes it possible to interact with target cell while blocking IL-1b/IL-1rb protein molecule.

Researchers conducted a chisquare analysis of 512 PTC sample and 58 normal tissue samples in order to determine the positive diagnostic utility of IL1RN. The results showed a significant correlation between IL1RN mRNA transcript levels, N and T stage of cancers and RAS status. IL1RN expression was also positively associated with overall survival. Boster Bio's IL1RN protein molecule may be useful in cancer treatment and diagnosis.

In addition to being found in a variety human cells, the IL1RN-like protein molecule also plays an important role in the biology coronaviruses. Boster Bio has a patented PicoKine ELISA Platform that researchers can use to analyze this molecule. On chromosome 22q14, you will find a IL1RN-like molecule.

Recent studies on mice lacking IL1RN showed that mice with a mutation found in Il1ra had lower portal tract-associated lymphoid tissue formation, a higher percentage of granuloma formation, and an increase in intrahepatic Th2 cytokine expression. The study authors suggested that IL1RN -like protein molecule could play a key role in the local immune system to granulomatous liver disease.

Applications of the IL1R1 marker

Recently, the IL1R1 protein was identified in human cancer cells. This marker is a potential molecular target for a variety of diseases. It has been associated with autoimmune diseases, metabolic syndromes and angiogenesis, as well as other diseases. Inflammation can also be linked to obesity and cardiovascular disease. This is why it is crucial to identify biomarkers and secreted factor and other biomarkers for diagnosing and understanding these diseases. Numerous studies have shown the IL1R1 genetic gene is a useful and reliable biomarker to diagnose and treat diseases related to inflammation.

IL1R1 was originally identified in circulating T cells. It has been discovered that it is expressed in all innate immune and select populations adaptive immune cells, supporting its importance in a variety biology processes. It has been found in both immune cells and non-immune tissues. This suggests that it modulates inflammation. Thus, a more sensitive IL-1R1 marker could help us find major IL-1 signaling targets in the periphery.

The interleukin-1 gene family includes the IL1R1 gene. It plays a role in the PF-EPN-A and ST-EPN-RELA subsets. It regulates many biological processes, including stemness and angiogenesis. It also contributes to the inflammatory response in cancer cells. These functions have been demonstrated by IL1R1 gene expression cells in ependymoma cancer samples.

In-vitro arthritis pain models are another use for the IL1R1 genes. In vivo arthritis pain models, inhibition of IL-1 signaling may provide the therapeutic efficacy of IL-1 treatment. However, more research is needed on the role of IL-1R1 and musculoskeletal symptoms. However, the results of the study are promising. It is not yet clear if IL-1R1 gene suppression inhibits arthritis progression in mice.