Interleukin-18 receptor 1 Antibodies

AND IL18R1 ELISA kits, Interleukin-18 receptor 1 Proteins

Many biological assays use antibodies to detect Interleukin-18 receptor 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Interleukin-18 receptor 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Interleukin-18 receptor 1 antibodies...

We validate the specificity of these antibodies to Interleukin-18 receptor 1 by testing them on tissues known to express IL18R1 positively and negatively. Browse below to find the IL18R1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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IL18R1 Infographic by Boster Bio

All IL18R1 Products

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Product

Figures

Specificity

Applications

Price

Human IL-18R1 ELISA Kit PicoKine®

6 Q&As

Human

ELISA

$499
Cat # EK1260
96 wells/kit, with removable strips.

Anti-IL18R IL18R1 Antibody

13 Q&As

Human

$360
Cat # A04252
100 µl

Anti-IL-18R (M270) IL18R1 Antibody

Human, Mouse, Rat

$405
Cat # A04252-1
100ul

Human IL-18 R alpha /IL-1 R5 Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ13478
Starting from 10ug

IL18R1 Overview

Facts about Interleukin-18 receptor 1.

IL18R1 3D structure. Source: alphafold

Interleukin-18 receptor 1 (IL18R1)

Within the IL18 receptor complex, responsible for the binding of This proinflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532).
Involved in IL18-mediated IFNG synthesis from T- helper 1 (Th1) cells (PubMed:10653850).

Contributes to IL18- induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity). .

Gene Information

Human
Gene Name:	IL18R1
Uniprot:	Q13478
Entrez:	8809

Family

Belongs to:

interleukin-1 receptor family

Alternative Names

CD218a; IL-1 R5; IL-1 Rrp; IL-18 R alpha; IL-18 R1; IL18R alpha; IL18R1; IL-18Ra

Molecular Weight

Mass (kDA):
62.304 kDA

Genomic Context


Human

Location:	2q12.1
Sequence:	2; NC_000002.12 (102355796..102398777)

Tissue Specificity

Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells (PubMed:10925275, PubMed:11046021, PubMed:10653850).

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

Inflammation
Neoplasms
Rheumatoid Arthritis
Autoimmune Reaction
Arthritis
Asthma
Autoimmune Diseases
Infective Disorder
Malignant Neoplasms
Degenerative Polyarthritis
Innate Immune Response
Autoimmunity
Tissue Adhesions

Crohn Disease
Graft-vs-host Disease
Hepatitis
Inflammatory Bowel Diseases
Carcinoma
Psoriasis
Communicable Diseases

Interacting Proteins

IL18

Pathways

Immune Response
Pathogenesis
Secretion
Cytokine Production
Cell Proliferation
Cell Activation
Interferon-gamma Production
Innate Immune Response
Cell Development
T Cell Activation
Cell Differentiation
Histone Acetylation
Inflammatory Response

Chemokine Production
Cell Maturation
Glycosylation
Hypersensitivity
Adaptive Immune Response
Reverse Transcription
Methylation

PTMs

Phosphorylation
Cleavage

Acetylation
Methylation

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL18R1

References

PMID: 8626725 by Parnet P., et al. IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP.

PMID: 9325300 by Torigoe K., et al. Purification and characterization of the human interleukin-18 receptor.