IKZF1 Antibodies

DNA-binding protein Ikaros (IKZF1)

Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594).

Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A component ) of the CD3-delta gene.

Gene Information

Human
Gene Name:	IKZF1
Uniprot:	Q13422
Entrez:	10320

Family

Belongs to:
Ikaros C2H2-type zinc-finger protein family

Alternative Names

DNA-binding protein Ikaros; hIk-1; IK1; IK1LyF-1; Ikaros (zinc finger protein); IKAROS family zinc finger 1 (Ikaros); Ikaros family zinc finger protein 1; Ikaros; IKAROSLymphoid transcription factor LyF-1; IKZF1; LYF1; LyF-1; LYF1PRO0758; PRO0758; zinc finger protein, subfamily 1A, 1 (Ikaros); ZNFN1A1; ZNFN1A1CLL-associated antigen KW-6

Molecular Weight

Mass (kDA):
57.528 kDA

Genomic Context

Human
Location:	7p12.2
Sequence:	7; NC_000007.14 (50303453..50405101)

Tissue Specificity

Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine.

Subcellular Localizations

Nucleus. In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events.; [Isoform Ik2]: Nucleus. In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events (By similarity).; [Isoform Ik6]: Cytoplasm.

Diseases

• Leukemia
• Acute Lymphocytic Leukemia
• Malignant Neoplasms
• Neoplasms
• Myeloid Leukemia
• Precursor B-cell Lymphoblastic Leukemia-lymphoma
• L1 Acute Lymphoblastic Leukemia
• Lymphoma
• Leukemogenesis
• Precursor T-cell Lymphoblastic Leukemia-lymphoma
• Myeloid Leukemia, Chronic
• Leukemia, Myelocytic, Acute
• Cell Transformation, Neoplastic

• Cytogenetic Abnormality
• Chromosomal Translocation
• Blast Phase
• Philadelphia Chromosome
• Hematologic Neoplasms
• Acute Leukemia
• Janiceps

Pathways

• Pathogenesis
• Localization
• Cell Differentiation
• Cell Cycle
• Chromatin Remodeling
• Lymphocyte Differentiation
• Cell Development
• Methylation
• Cell Growth
• Dna Methylation
• T Cell Differentiation
• Stem Cell Differentiation
• Histone Modification

• Histone Acetylation
• Cell Proliferation
• Dna Repair
• S Phase
• V(d)j Recombination
• Reverse Transcription
• Translation

PTMs

• Phosphorylation
• Methylation
• Acetylation
• Sumoylation

• Demethylation
• Deacetylation
• Cleavage
• Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IKZF1

Boster Bio - Best Uses Of The IKZF1 Marker

If you're looking into boster bio's Anti-Ikaros Purified IKZF1 Monoclonal Antibody you may be wondering how you can use this particular marker in your research. For credit on the product you can submit your results for species and applications. It's not all bad, this product is accessible to scientists from all over the world. Continue reading to learn what it can do for you.

Boster Bio Anti-Ikaros Purified IKZF1 Monoclonal Antibody

This Boster Bio Anti-Ikaros Purized IKZF1 Monoclonal Immunoglobulin (E-2) is suitable for the detection of Ikaros which is a member in the C2H2-type zinc finger family. It is available in multiple-conjugated as well as non-conjugated versions. The nuclear transcription factors belonging to the Ikaros family are transcription factor members that associate with DNA replication machinery and respond to events that signal. Both Ikaros and Helios attach to DNA sequences, and function as hemopoeetic-specific transcription factors.

This monoclonal antibody has been tested using SimpleChIP(r) and Enzymatic ChromatinIP Kits. It is available in a buffer that contains 10 mg sodium HEPES (pH 7.5), 150 mg NaCl, 50% glycerol and less than 0.02 percent sodium azide. Monoclonal antibody production is achieved by immunizing animals using synthetic peptides that resemble Arg439 in the human Ikaros protein.

Boster IKZF1 is a monoclonal antibody that is not approved for use in human medical research. The label on this product reads, "For Research Use Only." This product is not authorized or licensed by FDA. It is intended for research and development purposes only, and not for therapeutic purposes. To obtain product credits, contact Boster Bio. Our customer service representatives are standing by to answer your queries about Boster Bio Anti-Ikaros Purified IKZF1 Monoclonal Antibody.

Boster Bio Anti Ikaros Purfied IKZF1 Monclonal Immunoglobulin is a high-quality anti-Ikaros antibody that targets IKZF1. It recognizes IKZF1 via binding to chromosome 7, (q12.2) and the four zinc-finger sequences within its DNA binding domain. IKZF1 is found in lymphoid cells where it functions in the regulation of T specific gene transcription in T cells.

A variety of biomarkers can be used to confirm preeclampsia in pregnant women. The biomarkers include ratio of sFlt-1 and the PIGF, as well as the levels of PAPP-A, FN and ADAM-12. The method can also be used to detect preeclampsia by using FN fragments and PAPP-A.

Numerous companies manufacture monoclonal antigens and polyclonal antibodies. These companies make use of rabbits and chickens to produce monoclonal and polyclonal antibody. Both companies can provide custom monoclonal antibody as well in polyclonal antibody Fab fragments. Both companies offer high-quality, reliable monoclonal antibodies.

The analysis of cytokines produced by lymph nodes of immunized mice was performed using the boster bio Anti-Ikaros anti-IKZF1 monoclonal Antibody. Two hundred splenocytes (105) were seeded in triplicates in round bottom 96-well plates. Supernatants were harvested after 72 hours to allow sandwich ELISA analysis. BD Biosciences used a phosphosorption ELISA method to test the cytokines.

The Boster Bio Anti-Ikaros Purfied IKZF1 Monoclonal Immunoglobulin (BII) is an effective immunotherapy that inhibits the expansion of the SARS-CoV-2 virus. It increases bloodstream IFN-g production. It is anti-HLA class II restricted cytokine receptors, that guard against a variety of diseases.

Vero cells were grown at a density of at 25,000 cells per plate. Samples of serum from mice immunized were activated at 56°C for 30 min, de-complementated and then serially diluted in serum-free DMEM medium. Equal amounts of protein were extracted and separated using SDS-PAGE.