IKBKE Antibodies

Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE)

Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. After activation of viral RNA detectors, such as RIG- I-like receptors, partners with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X.

This action allows subsequent homodimerization and nuclear translocation of the IRF3 resulting in transcriptional activation of pro-inflammatory and antiviral genes such as IFNB. In order to establish such an antiviral state, IKBKE forms a number of diverse complexes whose composition depends on the type of cell and cellular stimuli.

Gene Information

Human
Gene Name:	IKBKE
Uniprot:	Q14164
Entrez:	9641

Family

Belongs to:
protein kinase superfamily

Alternative Names

EC 2.7.11; EC 2.7.11.10; I-kappa-B kinase epsilon; IKBKE; IKK epsilon; IKK-E; IKKEMGC125297; IKK-epsilon; IKKI; IKK-I; IKK-iMGC125295; Inducible I kappa-B kinase; inducible IkappaB kinase; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; inhibitor of nuclear factor kappa-B kinase subunit epsilon; KIAA0151IKK-related kinase epsilon; MGC125294

Molecular Weight

Mass (kDA):
80.462 kDA

Genomic Context

Human
Location:	1q32.1
Sequence:	1; NC_000001.11 (206470243..206496890)

Tissue Specificity

Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.

Subcellular Localizations

Cytoplasm. Nucleus. Nucleus, PML body. Targeting to PML nuclear bodies upon DNA damage is TOPORS-dependent (PubMed:20188669). Located diffusely throughout the cytoplasm but locates to punctate cytoplasmic bodies when coexpressed with TRIM6 (PubMed:24882218).

Diseases

• Inflammation
• Malignant Neoplasms
• Neoplasms
• Cell Transformation, Neoplastic
• Leukemia
• Carcinoma
• Tissue Adhesions
• Inflammatory Response
• Immunologic Deficiency Syndromes
• Arthritis
• Virus Diseases
• Infective Disorder
• Ectodermal Dysplasia

• Lymphoma
• Rheumatoid Arthritis
• Diabetes Mellitus
• Mammary Neoplasms
• Malignant Paraganglionic Neoplasm
• Bloch Sulzberger Syndrome
• Dysplasia

Interacting Proteins

• APPBP2
• CDC37
• DDX3X
• HSP90AB1
• IFIH1

• IRF3
• MAVS
• TANK
• TBK1
• TBKBP1

Pathways

• Cell Death
• Pathogenesis
• Immune Response
• Localization
• Inflammatory Response
• Cell Proliferation
• Secretion
• Cell Cycle
• Proteolysis
• Cell Growth
• Cell Activation
• Cytokine Production
• Induction Of Apoptosis

• Angiogenesis
• Cell Adhesion
• T Cell Activation
• Oncogenesis
• Sensitization
• Innate Immune Response
• Rna Interference

PTMs

• Phosphorylation
• Ubiquitination
• Cleavage
• Dephosphorylation
• Reduction
• Oxidation
• Acetylation

• Nitrosylation
• Methylation
• Sumoylation
• Acylation
• Biotinylation
• Farnesylation
• Geranylgeranylation

Research Areas

• Cancer
• Phospho-Specific
• Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IKBKE

Best Uses Of The IKBKE Marker

Boster Bio Antiphospho IK beta (Y199), a highly regarded protein, is used by scientists around world. Picoband(tm), an antibody collection, contains the protein. It reacts with human, mouse and rat samples. Boster Bio Antiphospho-IK beta (Y199) is composed of 5 mg of bovine serum albumin.

Boster Bio Anti-IKBKE Marker

The Anti-IKBKE Marker, developed by Boster Biologicals, is a novel antibody that can detect biomarkers in breast cancer cells. This antibody can detect biomarkers up to the picogram scale and has been used to identify breast cancer markers for more then a decade. It is available as an ELISA test kit and is used to detect biomarkers for cancer, developmental biology and inflammation.

Boster Bio Anti-Phospho-Phospho-IK beta

Boster Bio Antiphospho-phospho IK beta (Y199), is an antibody that can be used to test IKK beta levels. This highly respected antibody reacts with Rat, Mouse, Human IKK beta protein proteins. It has the unique ability of binding to seventy-8 amino acids in the sequence 728-745. This antibody, unlike other protein antigens can be stored for up to a full year at -20degC. Boster Bio Antiphospho–IK beta antibody comes in a 1 gram vial if you need to test it for a longer period.

Antibodies to IKBKB are used in many biological assays. Boster Bio developed its antibodies using antibodies made from rabbit and mouse. They are highly sensitive and specific which allows researchers to test for activators' effect on protein levels. In addition, Boster Bio's ELISA kits have a high throughput for rapid and easy analysis. The Boster Bio Antiphospho-IK beta antibody can be used to screen for specific isotypes.