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- Table of Contents
Facts about Protein Red.
Required for normal mitotic cell cycle progression (PubMed:22351768, PubMed:24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is needed to trigger the spindle assembly checkpoint (PubMed:22351768).
Human | |
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Gene Name: | IK |
Uniprot: | Q13123 |
Entrez: | 3550 |
Belongs to: |
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RED family |
chondrosarcoma-associated protein 2; CSA2; Cytokine IK; IK cytokine, down-regulator of HLA II; IK factor; MGC59741; protein Red; Protein RER; RD element; REDprer protein; RER
Mass (kDA):
65.602 kDA
Human | |
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Location: | 5q31.3 |
Sequence: | 5; NC_000005.10 (140647818..140662480) |
Ubiquitous.
Nucleus. Nucleus, nucleoplasm. Chromosome. Cytoplasm, cytoskeleton, spindle pole. Predominantly present throughout the nucleoplasm during prometaphase, metaphase and anaphase. Is also detected in nuclear foci that are not identical with Cajal bodies. Starts to accumulate at chromosomes during telophase, and is nearly exclusively associated with chromosomes in newly divided cells (PubMed:24252166). Colocalizes with MAD1L1 at mitotic spindle poles during metaphase and anaphase (PubMed:22351768).
PMID: 10216252 by Assier E., et al. Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat.
PMID: 7970704 by Krief P., et al. A new cytokine (IK) down-regulating HLA class II: monoclonal antibodies, cloning and chromosome localization.