IGHMBP2 Antibodies

AND IGHMBP2 ELISA kits, IGHMBP2 Proteins

Many biological assays use antibodies to detect IGHMBP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IGHMBP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IGHMBP2 antibodies...

We validate the specificity of these antibodies to IGHMBP2 by testing them on tissues known to express IGHMBP2 positively and negatively. Browse below to find the IGHMBP2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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IGHMBP2 Infographic by Boster Bio

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SMUBP2 (IGHMBP2) (NM_002180) Human Over-expression Lysate

Human

$628
Cat # LS003508
100 µg

IGHMBP2 Overview

Facts about DNA-binding protein SMUBP-2.

IGHMBP2 3D structure. Source: alphafold

DNA-binding protein SMUBP-2 (IGHMBP2)

5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator.

Required for the transcriptional activation of the flounder liver- type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron.

Gene Information

Human
Gene Name:	IGHMBP2
Uniprot:	P38935
Entrez:	3508

Family

Belongs to:

DNA2/NAM7 helicase family

Alternative Names

ATP-dependent helicase IGHMBP2; CATF1FLJ41171; EC 3.6.1; EC 3.6.4.12; EC 3.6.4.13; GF-1; Glial factor 1; HCSA; HMN6cardiac transcription factor 1; immunoglobulin mu binding protein 2; Immunoglobulin mu-binding protein 2; SMARD1DNA-binding protein SMUBP-2; SMBP2; SMUBP2FLJ34220

Molecular Weight

Mass (kDA):
109.149 kDA

Genomic Context


Human

Location:	11q13.3
Sequence:	11; NC_000011.10 (68903855..68940601)

Tissue Specificity

Expressed in all tissues examined. Expressed in the developing and adult human brain, with highest expression in the cerebellum. Moderately expressed in fibroblasts.

Subcellular Localizations

Nucleus. Cytoplasm. Cell projection, axon. Colocalizes with the translation initiation factor EIF4G2.

Diseases

Atrophy
Muscular Atrophy
Spinal Muscular Atrophy
Respiratory Distress
Spinal Muscular Atrophies Of Childhood
Respiratory Failure
Weakness
Muscle Weakness
Hmn (hereditary Motor Neuropathy) Proximal Type I
Respiratory Distress Syndrome, Newborn
Neuromuscular Diseases

Nerve Degeneration
Motor Neuron Disease
Hereditary Motor And Sensory Neuropathies
Diaphragm Muscle Weakness
Peripheral Motor Neuropathy
Dyspnea

Pathways

Muscle Atrophy
Pathogenesis
Transport
Dna Replication
Rna Processing
Trna Transcription
Translational Initiation
Cell Migration
Brain Development
Dna Repair
Localization

Myelination
Ribosome Biogenesis
Translation
Cell Motility
Lipid Homeostasis

PTMs

Hydroxylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IGHMBP2

References

PMID: 8349627 by Fukita Y., et al. The human S mu bp-2, a DNA-binding protein specific to the single- stranded guanine-rich sequence related to the immunoglobulin mu chain switch region.

PMID: 10049831 by Zhang Q., et al. Smubp-2 represses the Epstein-Barr virus lytic switch promoter.