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- Table of Contents
Facts about Immunoglobulin heavy constant gamma 3.
In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).
Human | |
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Gene Name: | IGHG3 |
Uniprot: | P01860 |
Entrez: | 3502 |
Belongs to: |
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No superfamily |
DKFZp686H11213; FLJ39988; FLJ40036; FLJ40253; FLJ40587; FLJ40789; FLJ40834; IgG3; immunoglobulin heavy constant gamma 3 (G3m marker); MGC45809
Mass (kDA):
41.287 kDA
Human | |
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Location: | 14q32.33 |
Sequence: | 14; NC_000014.9 (105765914..105771405, complement) |
Secreted. Cell membrane.
PMID: 6774747 by Frangione B., et al. Primary structure of human gamma 3 immunoglobulin deletion mutant: gamma 3 heavy-chain disease protein Wis.
PMID: 402363 by Michaelsen T.E., et al. Primary structure of the 'hinge' region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit.