IFNAR2 Antibodies

AND IFNAR2 ELISA kits, IFNAR2 Proteins

Many biological assays use antibodies to detect IFNAR2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IFNAR2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IFNAR2 antibodies...

We validate the specificity of these antibodies to IFNAR2 by testing them on tissues known to express IFNAR2 positively and negatively. Browse below to find the IFNAR2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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IFNAR2 Infographic by Boster Bio

All IFNAR2 Products

Product

Figures

Specificity

Applications

Price

Anti-IFN- alphaR2 IFNAR2 Antibody

4 Q&As

Human

IHC, WB

$399
Cat # A02056-1
100μl

Anti-IFNAR2 Antibody Picoband™

1 Citations 1 Q&As

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A02056-3
100 μg/vial

IFNAR2 (NM_207585) Human Over-expression Lysate

Human

$960
Cat # LS003455
100 µg

IFNAR2 Overview

Facts about Interferon alpha/beta receptor 2.

IFNAR2 3D structure. Source: alphafold

Interferon alpha/beta receptor 2 (IFNAR2)

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta.

Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction because of their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950).

Gene Information

Human
Gene Name:	IFNAR2
Uniprot:	P48551
Entrez:	3455

Family

Belongs to:

type II cytokine receptor family

Alternative Names

beta receptor10; human interferon alpha; human interferon alpha/beta receptor; IFNABR; IFN-alpha binding protein; IFN-alpha/beta R2; IFN-alpha/beta receptor 2; IFN-alpha-REC; IFNAR2; IFN-aR2; IFNARB; IFNbR2; IFN-bR2; IFN-R; IFN-R-2; interferon (alpha, beta and omega) receptor 2; Interferon alpha binding protein; interferon alpha/beta receptor 2; interferon-alpha/beta receptor beta chain; Type I interferon receptor 2

Molecular Weight

Mass (kDA):
57.759 kDA

Genomic Context


Human

Location:	21q22.11
Sequence:	21; NC_000021.9 (33229895..33265664)

Tissue Specificity

Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.

Subcellular Localizations

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.

Diseases

Hepatitis
Hepatitis C
Hepatitis, Chronic
Malignant Neoplasms
Neoplasms
Janiceps
Carcinoma
Sclerosis
Hepatitis C, Chronic
Multiple Sclerosis
Virus Diseases
Liver Carcinoma
Infective Disorder

Autoimmune Reaction
Lupus Erythematosus, Systemic
Liver Neoplasms
Autoimmune Diseases
Hepatitis B
Chimera Disorder
Vesicular Stomatitis

Interacting Proteins

CREBBP
IRF9
JAK1
RACK1
STAT1

STAT2
USP18

Pathways

Cell Proliferation
Proteolysis
Cell Cycle
Cell Growth
Pathogenesis
Secretion
Cell Cycle Arrest
Induction Of Apoptosis
Endocytosis
Immune Response
Hypersensitivity
Reverse Transcription
T Cell Proliferation

Localization
Response To Interferon-alpha
Receptor Internalization
Cell Death
S Phase
Viral Replication
Cell Adhesion

PTMs

Phosphorylation
Ubiquitination
Cleavage
Glycosylation

Demethylation
Acetylation
Methylation
Dephosphorylation

Iodination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IFNAR2

References

PMID: 8181059 by Novick D., et al. The human interferon alpha/beta receptor: characterization and molecular cloning.

PMID: 7588638 by Lutfalla G., et al. Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.

1 Publications of Boster IFNAR2 Antibodies & ELISA Kits

PubMed ID: 10.1016/j.colsurfb.2016.04.037, Preparation and characterization of latex films photo-immobilized with IFN-α

*More publications can be found for each product on its corresponding product page