IFNAR1 Antibodies

Interferon alpha/beta receptor 1 (IFNAR1)

Part of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions generally as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986).

Type I interferon binding activates the JAK-STAT signaling cascade, and activates tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).

Gene Information

Human
Gene Name:	IFNAR1
Uniprot:	P17181
Entrez:	3454

Family

Belongs to:
type II cytokine receptor family

Alternative Names

alpha-type antiviral protein; AVP; beta-type antiviral protein; CRF2-1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC; IFN-alpha/beta R1; IFN-alpha/beta receptor 1; IFN-alpha-REC; IFNAR; IFNAR1; IFN-aR1; IFNBR; IFNbR1; IFN-bR1; IFN-R-1; interferon (alpha, beta and omega) receptor 1; interferon alpha/beta receptor 1; interferon-alpha/beta receptor alpha chain; interferon-beta receptor 1; Type I interferon receptor 1

Molecular Weight

Mass (kDA):
63.525 kDA

Genomic Context

Human
Location:	21q22.11
Sequence:	21; NC_000021.9 (33324443..33360361)

Tissue Specificity

IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.

Subcellular Localizations

[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Late endosome. Lysosome. Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes.

Diseases

• Virus Diseases
• Hepatitis
• Infective Disorder
• Janiceps
• Neoplasms
• Hepatitis C
• Inflammation
• Multiple Sclerosis
• Sclerosis
• Hepatitis, Chronic
• Malignant Neoplasms
• Innate Immune Response
• Hepatitis C, Chronic

• Hepatitis B
• Carcinoma
• Nervousness
• Autoimmune Reaction
• Liver Carcinoma
• Lupus Erythematosus, Systemic
• Autoimmunity

Interacting Proteins

• FBXW11
• STAT1
• STAT2
• TYK2

Pathways

• Immune Response
• Pathogenesis
• Viral Replication
• Secretion
• Innate Immune Response
• Cell Proliferation
• Endocytosis
• Cell Death
• Cell Cycle
• Localization
• Cell Activation
• Virulence
• Inflammatory Response

• Induction Of Apoptosis
• Cell Growth
• Tropism
• Proteolysis
• Type I Interferon Production
• Cell Cycle Arrest
• Translation

PTMs

• Phosphorylation
• Ubiquitination
• Methylation
• Glycosylation
• Dephosphorylation

• Demethylation
• Isgylation
• Cleavage
• Acetylation
• Palmitoylation

• Iodination

Research Areas

• Neuroscience
• Phospho-Specific

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IFNAR1

Best Uses Of The IFNAR1 Marker

Anti-IFNAR1 ELISA Kits can detect the antiviral function of the IFNAR1 Marker. Boster Bio's PICOKINE(tm) ELISA kits can detect the protein of interest in the picogram range. For a comprehensive list of Boster Bio's product credits and benefits, please visit their website. We look forward to seeing you there!

Boster Bio's IFNAR1 Marker functions as an antiviral factor

The IFN-a/b response is very sensitive to temperature fluctuations, which reduces its antiviral efficacy at subnormal cellular temperatures and increases it at supranormal temperatures. This reaction involves altered transcription of genes that produce IFN response proteins, as well as temperature-dependent pathways. This alteration in transcription results in changes to the IFN response protein levels. Interestingly, the antiviral effect of the gene transcription demonstrates the opposite of the temperature effect.

The IFN-Is produced in the body cause flu-like symptoms, which may alert an infected individual to an infection and limit its spread. On the other hand, the SARS-CoV and MERS-CoV viruses suppress IFNb production and are associated with increased disease severity and mortality. In lethal cases, the influx of inflammatory cells is increased. In one study, an imbalance of IFN-I and inflammatory cells led to fatal pneumonia.

The IFNAR1 gene is located on 21q22.1. It has been sub-localized by Langer et al., and further refined by Lutfalla et al., by comparing its exon structure with other receptor genes. IFNAR1 has diverged from the immunoglobulin superfamily. Its localization is an advantage for the researchers who are working on the gene's function.

Boster Bio's Anti-IFNAR1 Marker

The IFNAR1 gene codes for the alpha chain of the interferon-alpha/beta receptor. Interferon-alpha/beta receptors are type I membrane proteins. When the receptors bind to certain antigens, they activate Janus protein kinases that phosphorylate several proteins and function as an antiviral factor. Several suppliers offer anti-IFNAR1 antibodies. Antibodies that target this gene are available as monoclonal or polyclonal antibodies. Some are available for mouse and canine orthologs.

Boster's Anti-IFNAR1 Markers were validated using known positive and negative samples to determine specificity and high affinity. Boster's products are backed by a robust validation process. As with all its products, Boster rewards the first reviewer with product credits. Boster offers this incentive to all scientists around the world. While it is still early to say whether Boster's Anti-IFNAR1 Marker is suitable for your research, it is worth checking out.

Boster Bio's PICOKINE(tm) ELISA kits reach picogram level sensitivity of your protein of interest

As an ELISA company, Boster develops research antibodies and ELISA kits that detect biomarkers in cancer, neuroscience, developmental biology, and inflammation. They provide excellent product quality and are backed by a Boster Quality Guarantee. They offer a variety of antibody-based immunological reagents and are actively expanding their product lines every month.

All Picokine ELISA kits are validated using biologically relevant matrices, including cell culture supernatants, serum, and plasma. They are thoroughly tested for inter and intra-assay variability, and Boster's proprietary coating and blocking technologies help ensure reproducibility. Validation images are provided on the Boster website.

PICOKINE ELISA kits are highly sensitive. These kits reach the picogram level sensitivity of your protein of interest. R&D Systems produces over six hundred and fifty ELISA kits and a wide variety of development systems. They offer comprehensive kits and ELISA development systems that span 12 species. Their quality and performance makes them one of the world's leading ELISA companies.

Whether you need to measure the concentration of a specific target on a single species or a variety of components, PICOKINE ELISA kits can detect a specific protein of interest. In addition to serum and plasma, they can be used to analyze protein lysates and cell culture supernates. PICOKINE ELISA kits are usually designed for 96-well microplates that contain a cover layer of antibody and an objective analyte.

These ELISA kits are made from highly specific primary antibodies, which allow for accurate detection of the desired protein of interest. They can also be used for cross-reactivity between two proteins. This is a convenient option when you want to detect multiple samples using a single antibody. Moreover, it eliminates the need for multiple steps and reduces the risk of cross-reactivity.

For sensitive detection of a specific protein of interest, PICOKINE ELISA kits are recommended by most laboratories. They reach picogram level sensitivity of your protein of interest in just two hours. The ELISA MAX Standard Set contains all the reagents you need and a 96-well strip plate coated with the capture antibody. These kits are recommended for researchers who are on a budget.

For sensitive detection of a protein of interest, choose a kit that reaches the picogram level sensitivity of your protein of choice. Choosing the appropriate ELISA kit is important for the results and the reproducibility of your results. To ensure accuracy, you must select the right ELISA plate and optimal conditions for plate-coating.

In order to achieve the highest sensitivity of your protein of interest, you must select antibodies that recognize distinct nonoverlapping epitopes on the antigen. Monoclonal antibodies are the most common choice because they have a high specificity of the primary antibody. For sandwich ELISA, it is important to select matched pairs of the detection antibodies and capture antibody.