Interferon-induced transmembrane protein 3 (IFITM3)

IFN-induced antiviral protein that disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses into the host cell cytoplasm by preventing viral combination with cholesterol depleted endosomes.

May inactivate new enveloped viruses that buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV).