IFI16 Antibodies

AND IFI16 ELISA kits, IFI16 Proteins

Many biological assays use antibodies to detect IFI16, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IFI16 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IFI16 antibodies...

We validate the specificity of these antibodies to IFI16 by testing them on tissues known to express IFI16 positively and negatively. Browse below to find the IFI16 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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IFI16 Infographic by Boster Bio

All IFI16 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-IFI16 Antibody

5 Q&As

Human

$360
Cat # A00848
100 µl

Anti-IFI16 Antibody

1 Q&As

Human, Mouse, Rat

ELISA, WB

$335
Cat # A30690
100ul

Anti-IFI-16 Antibody

Human

$405
Cat # A00848-2
100ul

Anti-IFI16 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A00848-3
100 μg/vial

IFI16 (NM_005531) Human Over-expression Lysate

Human

$628
Cat # LS003428
100 µg

Anti-IFI16 Antibody Picoband® (monoclonal, 2I3D7)

Human

Flow Cytometry, IF, ICC, WB

$370
Cat # M00848
100 μg/vial

IFI16 Overview

Facts about Gamma-interferon-inducible protein 16.

IFI16 3D structure. Source: alphafold

Gamma-interferon-inducible protein 16 (IFI16)

Seems to be involved in transcriptional regulation. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes.

Controls cellular proliferation by regulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and regulating TP53 phosphorylation status.

Gene Information

Human
Gene Name:	IFI16
Uniprot:	Q16666
Entrez:	3428

Family

Belongs to:

HIN-200 family

Alternative Names

ifi-16; IFNGIP1gamma-interferon-inducible protein 16; interferon, gamma-inducible protein 16; interferon-gamma induced protein IFI 16; Interferon-inducible myeloid differentiation transcriptional activator; MGC9466; PYHIN2

Molecular Weight

Mass (kDA):
88.256 kDA

Genomic Context


Human

Location:	1q23.1
Sequence:	1; NC_000001.11 (158999976..159055151)

Tissue Specificity

Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prostate, ovary and breast (at protein level).

Subcellular Localizations

Nucleus. Cytoplasm. Cellular distribution is dependent on the acetylation status of the multipartite nuclear localization signal (NLS); NLS acetylation promotes cytoplasmic localization. Localizes in the nucleus during human herpes simplex virus 1 (HHV-1) infection.

Diseases

Neoplasms
Malignant Neoplasms
Carcinoma
Autoimmune Reaction
Lupus Erythematosus, Systemic
Autoimmune Diseases
Melanoma
Autoimmunity
Retinoblastoma
Inflammation
Growth Arrest
Tissue Adhesions

Innate Immune Response
Cell Transformation, Neoplastic
Sting Injury
Cytomegalovirus Infections
Sjogren's Syndrome
Malignant Squamous Cell Neoplasm
Adenocarcinoma

Interacting Proteins

AR
BRCA1
DHX58
TMEM173
TP53

Pathways

Cell Growth
Cell Cycle
Cell Proliferation
Localization
Senescence
Cellular Senescence
Immune Response
Pathogenesis
Cell Cycle Arrest
Cell Differentiation
Cell Death
G1 Phase
Osteoblast Differentiation

Nuclear Export
Tube Morphogenesis
Inflammatory Response
Myeloid Cell Differentiation
Rna Interference
Cell Adhesion
Embryo Development

PTMs

Phosphorylation
Cleavage
Glycosylation

Acetylation
Dephosphorylation
Ubiquitination

Research Areas

Cytokine Research

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IFI16

References

PMID: 1526658 by Trapani J.A., et al. A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells.

PMID: 7959953 by Trapani J.A., et al. Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization.