IBTK Antibodies

AND IBTK ELISA kits, IBTK Proteins

Many biological assays use antibodies to detect IBTK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IBTK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IBTK antibodies...

We validate the specificity of these antibodies to IBTK by testing them on tissues known to express IBTK positively and negatively. Browse below to find the IBTK antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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IBTK Infographic by Boster Bio

All IBTK Products

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Specificity

Applications

Price

Anti-IBTK Antibody

Human

$405
Cat # A07985
100ul

IBTK (NM_015525) Human Over-expression Lysate

Human

$960
Cat # LS025998
100 µg

IBTK Overview

Facts about Inhibitor of Bruton tyrosine kinase.

IBTK 3D structure. Source: alphafold

Inhibitor of Bruton tyrosine kinase (IBTK)

Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.

Gene Information

Human
Gene Name:	IBTK
Uniprot:	Q9P2D0
Entrez:	25998

Family

Belongs to:

No superfamily

Alternative Names

Bruton agammaglobulinemia tyrosine kinase inhibitor; BTK-binding protein; BTKI; DKFZP564B116; IBtk; inhibitor of Bruton agammaglobulinemia tyrosine kinase; inhibitor of Bruton tyrosine kinase; inhibitor of Bruton's tyrosine kinase; inhibitor of Bruton's tyrosine kinase-alpha; inhibitor of Bruton's tyrosine kinase-beta; inhibitor of Bruton's tyrosine kinase-gamma; KIAA1417; MGC142256; MGC142258; RP1-93K22.1

Molecular Weight

Mass (kDA):
150.528 kDA

Genomic Context


Human

Location:	6q14.1
Sequence:	6; NC_000006.12 (82169987..82247747, complement)

Tissue Specificity

Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues.

Subcellular Localizations

Cytoplasm. Membrane; Peripheral membrane protein. Translocates to the plasma membrane upon IgM stimulation.; [Isoform 2]: Nucleus.

Diseases

Immunologic Deficiency Syndromes
Agammaglobulinemia
X-linked Agammaglobulinemia
Cytogenetic Abnormality
Lymphoproliferative Disorders
Malignant Neoplasms
Corneal Diseases
Glaucoma, Open-angle

Glaucoma
Primary Open Angle Glaucoma

Pathways

Translation
Cell Development
Regulation Of Gene Expression

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IBTK

References

PMID: 18596081 by Spatuzza C., et al. Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk.

PMID: 11577348 by Liu W., et al. Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein.