Hey1 Antibodies

AND Hey1 ELISA kits, Hey1 Proteins

Many biological assays use antibodies to detect Hey1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Hey1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Hey1 antibodies...

We validate the specificity of these antibodies to Hey1 by testing them on tissues known to express Hey1 positively and negatively. Browse below to find the Hey1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Hey1 Infographic by Boster Bio

All Hey1 Products

Product

Figures

Specificity

Applications

Price

Anti-HEY1 Antibody

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A02454-1
100ul

Anti-HEY1 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A02454-2
100ul

HEY1 (NM_012258) Human Over-expression Lysate

Human

$628
Cat # LS023462
100 µg

Hey1 Overview

Facts about Hairy/enhancer-of-split related with YRPW motif protein 1.

Hairy/enhancer-of-split related with YRPW motif protein 1 (Hey1)

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development.

Especially required for its Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in combination with HEY2 to specify arterial cell fate or individuality.

Gene Information

Mouse
Gene Name:	Hey1
Uniprot:	Q9WV93
Entrez:	15213

Family

Belongs to:

HEY family

Alternative Names

basic helix-loop-helix protein OAF1; BHLHb31; Cardiovascular helix-loop-helix factor 2; CHF-2; CHF2hHRT1; Class B basic helix-loop-helix protein 31; Hairy and enhancer of split-related protein 1; hairy/enhancer-of-split related with YRPW motif 1; hairy/enhancer-of-split related with YRPW motif protein 1; Hairy-related transcription factor 1; HERP2HES-related repressor protein 1; HESR-1; HESR1MGC1274; HES-related repressor protein 2; HRT1; HRT-1OAF1

Molecular Weight

Mass (kDA):
32.063 kDA

Genomic Context


Mouse

Location:	3 A1\|3 2.15 cM
Sequence:	3;

Tissue Specificity

Expressed in somitic mesoderm, brain, central nervous system, kidney, heart, nasal epithelium, limbs, lung, muscle, ovary and testis.

Diseases

Neoplasms
Malignant Neoplasms
Tumor Angiogenesis
Cell Transformation, Neoplastic
Idiopathic Hypereosinophilic Syndrome
Carcinoma
Sarcoma
Pathologic Neovascularization
Leukemia
Nervousness
Hypoxia
Malignant Neoplasm Of Lung

Neuroblastoma
Malignant Neoplasm Of Breast
Brain Neoplasms
Congenital Heart Defects
Malignant Neoplasm Of Pancreas
Malignant Neoplasm Of Stomach
Carcinogenesis

Pathways

Notch Signaling Pathway
Cell Proliferation
Angiogenesis
Cell Cycle
Pathogenesis
Osteoblast Differentiation
Cell Differentiation
Regeneration
Cell Growth
Vasculogenesis
Somitogenesis
Oncogenesis
Tube Formation

Neurogenesis
Cell Cycle Arrest
Localization
Cell Death
Cell Division
Lateral Inhibition
Epithelial Cell Proliferation

PTMs

Phosphorylation
Cleavage
Ubiquitination

Deacetylation
Acetylation
Methylation

Research Areas

DNA Repair
DNA replication, Transcription, Translation and Splicing
Neuroscience
Transcription Factors and Regulators

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Hey1

References

PMID: 10403790 by Kokubo H., et al. Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split.

PMID: 10415358 by Leimeister C., et al. Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis.