Hyaluronidase-2 Antibodies

AND HYAL2 ELISA kits, Hyaluronidase-2 Proteins

Many biological assays use antibodies to detect Hyaluronidase-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Hyaluronidase-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Hyaluronidase-2 antibodies...

We validate the specificity of these antibodies to Hyaluronidase-2 by testing them on tissues known to express HYAL2 positively and negatively. Browse below to find the HYAL2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HYAL2 Infographic by Boster Bio

All HYAL2 Products

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Product

Figures

Specificity

Applications

Price

Anti-Hyaluronidase-2 HYAL2 Antibody Picoband®

7 Q&As

Human, Mouse, Rat

$370
Cat # PA1817
100 μg/vial

HYAL2 (NM_003773) Human Over-expression Lysate

Human

$628
Cat # LS008692
100 µg

HYAL2 Overview

Facts about Hyaluronidase-2.

HYAL2 3D structure. Source: alphafold

Hyaluronidase-2 (HYAL2)

Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product that's further hydrolyzed by sperm hyaluronidase to give tiny oligosaccharides. Displays very low levels of activity.

Associates with and negatively regulates MST1R. .

Gene Information

Human
Gene Name:	HYAL2
Uniprot:	Q12891
Entrez:	8692

Family

Belongs to:

glycosyl hydrolase 56 family

Alternative Names

EC 3.2.1.35; Hyal-2; hyaluronidase 2; hyaluronoglucosaminidase 2; hyaluronoglucosaminidase-2; LuCa-2; LUCA2hyaluronidase-2; Lung carcinoma protein 2; lysosomal hyaluronidase; PH20 homolog; PH-20 homolog

Molecular Weight

Mass (kDA):
53.86 kDA

Genomic Context


Human

Location:	3p21.31
Sequence:	3; NC_000003.12 (50317790..50322850, complement)

Tissue Specificity

Widely expressed. No expression detected in adult brain.

Subcellular Localizations

Cell membrane; Lipid-anchor, GPI-anchor.

Diseases

Neoplasms
Headache
Malignant Neoplasms
Pulmonary Adenomatosis, Ovine
Malignant Neoplasm Of Lung
Lung Neoplasms
Carcinoma
Adenocarcinoma
Cell Transformation, Neoplastic
Inflammation
Neoplasm Metastasis
Malignant Neoplasm Of Breast

Malignant Paraganglionic Neoplasm
Cell Invasion
Non-small Cell Lung Carcinoma
Tumor Angiogenesis
Tissue Adhesions
Mammary Neoplasms
Malignant Squamous Cell Neoplasm

Interacting Proteins

FHL3
KRTAP3-2

Pathways

Localization
Cell Growth
Cell Proliferation
Wound Healing
Oncogenesis
Methylation
Cell Migration
Angiogenesis
Cell Motility
Tropism
Glycosylation
Cell Death
Aging

Fibroblast Proliferation
Chondrocyte Differentiation
Cartilage Development
Mrna Transcription
System Development
Metabolic Process
Cell Cycle

PTMs

Methylation
Cleavage
Glycosylation
Gpi Anchoring
Sulphation

Demethylation
Phosphorylation
Biotinylation
Reduction
Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HYAL2

References

PMID: 9712871 by Lepperdinger G., et al. HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity.

PMID: 11731268 by Lepperdinger G., et al. Hyal2 -- less active, but more versatile?