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Huntingtin Antibodies
AND HTT ELISA kits, Huntingtin Proteins
Many biological assays use antibodies to detect Huntingtin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Huntingtin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Huntingtin antibodies...
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HTT Infographic by Boster Bio
All HTT Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00134
100 μl
Cat # M00134
100 μl
HTT Overview
Facts about Huntingtin.
Huntingtin (HTT)
May play a role in microtubule-mediated transport or vesicle function. .
Gene Information
| Human | |
|---|---|
| Gene Name: | HTT |
| Uniprot: | P42858 |
| Entrez: | 3064 |
Family
| Belongs to: |
|---|
| huntingtin family |
Alternative Names
HD protein; huntingtin (Huntington disease); huntingtin; IT15HDHuntington disease protein
Molecular Weight
Mass (kDA):
347.603 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4p16.3 |
| Sequence: | 4; NC_000004.12 (3074681..3243960) |
Tissue Specificity
Expressed in the brain cortex (at protein level). Widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation.
Subcellular Localizations
[Huntingtin]: Cytoplasm. Nucleus. Early endosome. The mutant Huntingtin protein colocalizes with AKAP8L in the nuclear matrix of Huntington disease neurons. Shuttles between cytoplasm and nucleus in a Ran GTPase-independent manner (PubMed:15654337). Recruits onto early endosomes in a Rab5- and HAP40-dependent fashion (PubMed:16476778).; [Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome.
Diseases
- Huntington Disease
- Neurodegenerative Disorders
- Nerve Degeneration
- Trinucleotide Repeat Expansion
- Atrophy
- Neuropathology Disease
- Chorea
- Neurotoxicity Syndromes
- Alzheimer's Disease
- Nervousness
- Nervous System Disorder
- Impaired Cognition
- Ataxia
Pathways
- Pathogenesis
- Cell Death
- Localization
- Transport
- Autophagy
- Rna Interference
- Proteolysis
- Translation
- Neuroprotection
- Synaptic Transmission
- Neurogenesis
- Protein Folding
- Endocytosis
PTMs
- Cleavage
- Phosphorylation
- Ubiquitination
- Acetylation
- Sumoylation
- Palmitoylation
- Dephosphorylation
- Oxidation
- Methylation
Research Areas
- Apoptosis
- Autophagy
- Cell Biology
- Cellular Markers
- Neurodegeneration
- Neuronal Cell Markers
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HTT
bosterbio.com/bosterbio-gene-info-cards/HTT
References
PMID: 8458085 by Macdonald M., et al. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.
PMID: 11013077 by Matsuyama N., et al. Identification and characterization of the miniature pig Huntington's disease gene homolog: evidence for conservation and polymorphism in the CAG triplet repeat.