HTR2A Antibodies

5-hydroxytryptamine receptor 2A (HTR2A)

Also functions as a receptor for a variety of drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4- iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that activates signaling through guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538).

Beta-arrestin family members inhibit signaling through G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system which modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores (PubMed:18703043, PubMed:28129538).

Gene Information

Human
Gene Name:	HTR2A
Uniprot:	P28223
Entrez:	3356

Family

Belongs to:
G-protein coupled receptor 1 family

Alternative Names

5-HT2 receptor; 5-HT-2; 5HT2A; 5-HT2A; 5-HT-2A; 5-hydroxytryptamine (serotonin) receptor 2A; 5-hydroxytryptamine receptor 2A; HTR2,5-HT2A; HTR2A; serotonin 5-HT-2A receptor; Serotonin receptor 2A

Molecular Weight

Mass (kDA):
52.603 kDA

Genomic Context

Human
Location:	13q14.2
Sequence:	13; NC_000013.11 (46831542..46897076, complement)

Tissue Specificity

Detected in brain cortex (at protein level). Detected in blood platelets.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Cytoplasmic vesicle. Membrane, caveola. Cell junction, synapse, presynapse.

Diseases

• Depressive Disorder
• Schizophrenia
• Mental Disorders
• Major Depressive Disorder
• Dysequilibrium Syndrome
• Bipolar Disorder
• Attention Deficit Hyperactivity Disorder
• Mood Disorders
• Psychotic Disorders
• Cancer Patients And Suicide And Depression
• Anxiety Disorders
• Malnutrition

• Autistic Disorder
• Obsessive-compulsive Disorder
• Depressive Symptom
• Variable Number Tandem Repeat
• Alzheimer's Disease
• Cholangiocarcinoma

Interacting Proteins

• CNR1
• GRM2
• HTR1A
• HTR2B
• HTR2C

• Rps6ka3

Pathways

• Pathogenesis
• Methylation
• Transport
• Dna Methylation
• Localization
• Aging
• Brain Development
• Response To Clozapine
• Response To Risperidone
• Cell Adhesion
• Myelination
• Cognition

• Chromatin Remodeling
• Cell Death
• Secretion
• Programmed Cell Death
• Gene Silencing
• Immune Response
• Pigmentation

PTMs

• Methylation

• Acetylation

Research Areas

• GPCR

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HTR2A

Boster Bio - Best Uses Of The HTR2A Marker

Boster Bio's Anti Htr2a is a trusted antibody for researchers and scientists looking to analyze HTR2A proteins. This antibody can be used for a variety of applications, including research and biotechnology and cancer research. Here are a few of most important applications for this product, as well as its history.

Boster Bio Anti-Htr2a antibody

There are a variety of suppliers of anti-HTR2A antibodies. These antibodies are designed for the 5HT2A receptor protein. The protein is 52.6 Kilodaltons in size, with orthologs that are found in both the canine and porcine genomes. Additionally it is used to detect anti-HTR2A antibody to monitor the activity of this protein.

The HTR2A receptor is part of the family of serotonin receptors. It is a G-protein coupled receptor that has an inhibitory and excitatory affect on certain regions of the brain. It was initially considered as a potential target for psychedelic drugs. Scientists only recently began to acknowledge its importance in other research.

Boster's story

The last name Boster is widely used in The United States, but Boster is prevalent in Egypt, Malawi, and Egypt. Despite this spread the spelling of Boster changed over the centuries. Between 1880 and 2014, the number of people bearing the name Boster rose by 724 percent. However, the number of people with the name Boster fell by an average of 82 percent. Here are the most popular variants of the last name Boster.

Sharla M. Fett is a medical historian who uses different disciplines to study the history of slavery in the Americas and disability in the Americas. She also studies the interplay between race and disability in plantation societies. She introduces concepts, methods and theories that aren't commonly employed in traditional slavery studies. The book also describes the complex network of institutions and individuals that have shaped the development of disability history. This variety of perspectives has given us a better understanding of this complicated history of disability.