Heat shock protein 105 kDa (HSPH1)

Acts as a nucleotide-exchange variable (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly.

Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). .