HSD17B8 Antibodies

AND HSD17B8 ELISA kits, HSD17B8 Proteins

Many biological assays use antibodies to detect HSD17B8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HSD17B8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HSD17B8 antibodies...

We validate the specificity of these antibodies to HSD17B8 by testing them on tissues known to express HSD17B8 positively and negatively. Browse below to find the HSD17B8 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HSD17B8 Infographic by Boster Bio

All HSD17B8 Products

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Product

Figures

Specificity

Applications

Price

Anti-HSD17B8 Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A08741
100ul

Human HSD17B8 Recombinant Protein

SDS-PAGE

$265
Cat # PROTQ92506
Starting from 20ug

Anti-HSD17B8 Mouse Monoclonal Antibody [Clone ID: OTI6H2]

Dog, Human, Mouse, Rat

IHC, WB

$523
Cat # M08741
100 µl

Anti-HSD17B8 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A08741-1
100 μg/vial

HSD17B8 (NM_014234) Human Over-expression Lysate

Human

$628
Cat # LS007923
100 µg

HSD17B8 Overview

Facts about Estradiol 17-beta-dehydrogenase 8.

HSD17B8 3D structure. Source: alphafold

Estradiol 17-beta-dehydrogenase 8 (HSD17B8)

NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone (PubMed:17978863).

The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thus plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508).

Gene Information

Human
Gene Name:	HSD17B8
Uniprot:	Q92506
Entrez:	7923

Family

Belongs to:

short-chain dehydrogenases/reductases (SDR) family

Alternative Names

D6S2245EdJ1033B10.9; EC 1.1.1.-; EC 1.1.1.62; EC 1.1.1.63,17-beta-HSD 8; estrogen 17-oxidoreductase; FABGLestradiol 17-beta-dehydrogenase 8; H2-KE6; HKE6FabG (beta-ketoacyl-[acyl-carrier-protein] reductase, E coli) like (E. coli); hydroxysteroid (17-beta) dehydrogenase 8,3-oxoacyl-[acyl-carrier-protein] reductase; KE6; ke-6; Ke-6,17-beta-hydroxysteroid dehydrogenase 8; Protein Ke6; Really interesting new gene 2 protein; RING2FABG; SDR30C1; short chain dehydrogenase/reductase family 30C, member 1; Testosterone 17-beta-dehydrogenase 8

Molecular Weight

Mass (kDA):
26.974 kDA

Genomic Context


Human

Location:	6p21.32
Sequence:	6; NC_000006.12 (33204655..33206831)

Tissue Specificity

Highly expressed in placenta, liver and pancreas, lower in the skeletal muscle and kidney. Widely expressed.

Subcellular Localizations

Mitochondrion matrix.

Diseases

Neoplasm Metastasis
Neoplasms
Malignant Squamous Cell Neoplasm
Malignant Neoplasms
Head And Neck Neoplasms
Metastatic Malignant Neoplasm To The Lymph Node
Liver Carcinoma
Colorectal Neoplasms
Head And Neck Carcinoma

Tissue Adhesions
Colorectal Cancer
Carcinoma

Pathways

Transport
Cell Adhesion
Cell Cycle

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HSD17B8

References

PMID: 8812499 by Ando A., et al. cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region.

PMID: 17978863 by Ohno S., et al. Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8.