HSD17B4 Antibodies

Peroxisomal multifunctional enzyme type 2 (HSD17B4)

Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids.

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Gene Information

Human
Gene Name:	HSD17B4
Uniprot:	P51659
Entrez:	3295

Family

Belongs to:
short-chain dehydrogenases/reductases (SDR) family

Alternative Names

12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; 7-alpha; D-bifunctional protein; EDH17B4; hydroxysteroid (17-beta) dehydrogenase 4; MPF-2; peroxisomal multifunctional enzyme type 2,17-beta-HSD IV; peroxisomal multifunctional protein 2,17beta-estradiol dehydrogenase type IV; peroxisomal; short chain dehydrogenase/reductase family 8C, member 1,3-alpha

Molecular Weight

Mass (kDA):
79.686 kDA

Genomic Context

Human
Location:	5q23.1
Sequence:	5; NC_000005.10 (119452497..119542332)

Tissue Specificity

Present in many tissues with highest concentrations in liver, heart, prostate and testis.

Subcellular Localizations

Peroxisome.

Diseases

• Peroxisomal Disorders
• Protein Deficiency
• Malignant Neoplasms
• Zellweger Syndrome
• Adrenoleukodystrophy
• Neoplasms
• Malignant Neoplasm Of Prostate
• Prostatic Neoplasms
• Refsum Disease
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Muscle Hypotonia

• Neoplasms, Germ Cell And Embryonal
• Testicular Germ Cell Tumor
• Sensorineural Hearing Loss (disorder)
• Carcinoma
• Gonadal Dysgenesis Xx Type Deafness
• Germ Cell Tumor

Pathways

• Fatty Acid Beta-oxidation
• Conjugation
• Methylation
• Dna Methylation
• Fatty Acid Oxidation
• Transport
• Cell Growth
• Pathogenesis
• Aging
• Brain Development
• Oxidative Phosphorylation
• Dosage Compensation
• Spermatogenesis

• Myelination
• Mrna Transcription
• Fatty Acid Transport
• Gliogenesis
• Lipid Homeostasis
• Cell Differentiation
• Protein Import

PTMs

• Oxidation
• Methylation
• Hydroxylation

• Cleavage
• Phosphorylation
• Carboxylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HSD17B4

Boster Bio Antibodies - Best Uses Of The HSD17B4 Marker

If you're in search of high-affinity antibodies for studying HSD17B4, Boster Bio is the company for you. Boster Bio provides a range of primary antibodies that are high-affinity and secondary antibodies. Find out more about Boster's products and how you can use them to identify the antigen that you are looking for in your research. Boster's products have been validated across a variety of platforms and compared with positive and negative samples to ensure high specificity and affinity. Boster provides credit on its products to scientists from all over the world, as well as generous rewards for early reviewers.

Boster Bio provides high-affinity primary antibodies

For research projects that require an antibody that is highly specific against the HSD17B4 protein, Boster Bio has developed a line of antisera that has the catalog number PA1727. This monoclonal antibody reacts with human mouse, rat, and human samples. It is constructed from high-quality rabbit polyclonal antisera with high-affinity. Boster has a range of primary antibodies. The antibodies they offer are validated by Western Blotting, Immunohistochemistry, and ELISA to ensure high sensitivity.

Fabs are produced by subcloning heavy-chain Fv DNA into an IgG plasmid virus vector. This vector is then transfected into CHO or 293 cells. The supernatant that is produced from these cells is used to collect the antibodies, in addition to other suitable host cells. Other suitable hosts for Fab production include algae and bacteria and non-human transgenic hosts include rats, mice and goats.

A high-affinity antigen can bind to the HSD17B4 proteins with a high affinity. These antibodies aren't suitable for use in clinical trials however they are excellent instruments for research and development. The antibodies are covered for one year from the date of purchase. The company also provides an extensive selection of other antibodies, including chimeric ones. There are numerous advantages to using primary antibodies.

Bispecific antibodies bind to an epitope of an antigen. They stimulate T cells to produce antiviral proteins. They also function without co-stimulatory molecules, or MHC I. The infected cells then undergo apoptosis similar to the physiological response to a T cell attack.

In recent studies, deep sequencing of human B cells has been performed on an enormous scale. The data obtained allow for statistical analysis of specific features of the antibody sequence that are common to healthy humans. The resulting database allows for the estimation of the Human Likeness of antibody sequences which could have advantages in the development of therapeutic vaccines and antibodies. This technology could revolutionize immunotherapy research and allow for a more understanding of the human immune responses.

Recent outbreaks have been mostly caused by genogroup II genotype 4. New strains are emerging every two to three years. The Sydney strain was first identified in 2012 and continues dominating the list of strains in circulation. Although the molecular basis of antibody-mediated recognition HSD17B4 by antibodies is not fully understood, these antibodies can significantly enhance the accuracy of diagnostic tests.

The HSD17B4 marker may be very variable, so the best antibody should have at least three antigen binding sites. The ideal antibody should have between three and eight antigen-binding sites. The most effective multivalent antibody should have at omphoum two polypeptide chains and two different regions. Consider polypeptide chains that have at least four antigen binding sites to increase your antigen-binding site count.

The most widely used antibody against HSD17B4 is the polyclonal antibody with a gamma chain. However certain companies also offer recombinant antibody against one protein. This antibody is made up of an IgGi heavy chains and a biotin/avidin conjugated mole, that allows it to bind two antisera.

Boster provides high-affinity secondary antibodies.

If you are interested in using these antibodies for immunohistochemistry, Boster Bio offers a variety of high-affinity products. These products are designed for multiple applications, including immunohistochemistry, molecular biology, and protein analysis. Monoclonal antibodies are also available made from DNA sequences and can recognize multiple epitopes within a single antigen. Monoclonal antibodies possess a high affinity but greater variability between baths.

There are two types of secondary antibodies: liquid and lyophilized antibodies. Liquid secondary antibodies are easy to aliquote for storage over a long period and lyophilized secondary antibodies require a reagent in order to reconstitute them. In addition, they reduce the chance of losing performance liquid antibodies can be stored for many years at room temperature and can be frozen for preparation of working solutions.

Primary antibodies are created by immunizing an animal with a particular antibody. For example, if a goat is immunized with mouse IgG and produced, it will produce goat anti-mouse antibodies that attach to any type of mouse IgG and its fragments. A goat that has been immunized mouse IgG1 produces goat anti-mouse antibodies that are specific to the IgG1 class.

Apart from monoclonal antibodies, Boster Bio also offers high-affinity secondary antibodies against the protein marker HSD17B4. These products can be used to conduct extensive research into prostate disease markers or protein markers. The company has been in existence since 2006 and has a solid track-record in the biotechnology sector. You can purchase these products at Boster Bio and benefit from their exceptional quality and high affinity.