HSD11B2 Antibodies

AND HSD11B2 ELISA kits, HSD11B2 Proteins

Many biological assays use antibodies to detect HSD11B2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HSD11B2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HSD11B2 antibodies...

We validate the specificity of these antibodies to HSD11B2 by testing them on tissues known to express HSD11B2 positively and negatively. Browse below to find the HSD11B2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HSD11B2 Infographic by Boster Bio

All HSD11B2 Products

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Specificity

Applications

Price

Anti-HSD11B2 Antibody Picoband®

4 Q&As

Human, Mouse, Rat

IF, IHC, IHC-F, WB

$370
Cat # RP1094
100 μg/vial

Anti-HSD11B2 Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, IHC, WB

$370
Cat # A01613
100 μg/vial

HSD11B2 Overview

Facts about Corticosteroid 11-beta-dehydrogenase isozyme 2.

HSD11B2 3D structure. Source: alphafold

Corticosteroid 11-beta-dehydrogenase isozyme 2 (HSD11B2)

Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.

Gene Information

Human
Gene Name:	HSD11B2
Uniprot:	P80365
Entrez:	3291

Family

Belongs to:

short-chain dehydrogenases/reductases (SDR) family

Alternative Names

11 betaHSD2; 11 beta-HSD2; AME; corticosteroid 11-beta-dehydrogenase isozyme 2,11-beta-HSD2; EC 1.1.1; EC 1.1.1.-; HSD11B2; HSD11KAME1; HSD2,11-DH2; hydroxysteroid (11-beta) dehydrogenase 2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; SDR9C3; short chain dehydrogenase/reductase family 9C member 3,11-beta-hydroxysteroid dehydrogenase type 2

Molecular Weight

Mass (kDA):
44.127 kDA

Genomic Context


Human

Location:	16q22.1
Sequence:	16; NC_000016.10 (67431121..67437553)

Tissue Specificity

Expressed in kidney, pancreas, prostate, ovary, small intestine and colon. At midgestation, expressed at high levels in placenta and in fetal kidney and, at much lower levels, in fetal lung and testis (PubMed:8530071).

Subcellular Localizations

Microsome. Endoplasmic reticulum.

Diseases

Hypertensive Disease
Cortisol 11-beta-ketoreductase Deficiency
Mineralocorticoid Excess Syndrome, Apparent
Essential Hypertension
Obesity
Hypernatremia
Cushing Syndrome
Kidney Diseases
Fetal Growth Retardation
Hypokinesia
Alkalosis
Kidney Failure, Chronic
Diabetes Mellitus

Neoplasms
Insulin Resistance
Acth Syndrome, Ectopic
Malignant Neoplasms
Adenoma
Hyperaldosteronism
Hereditary Diseases

Pathways

Excretion
Secretion
Localization
Methylation
Pathogenesis
Transport
Cell Proliferation
Gluconeogenesis
Dna Methylation
Cortisol Secretion
Cell Growth
Luteinization
Aging

Water Transport
Luteolysis
Ovulation
Hatching
Response To Water Deprivation
Osteoblast Differentiation
Fertilization

PTMs

Methylation
Cleavage
Oxidation

Demethylation
Phosphorylation
Deacetylation

Acetylation

Research Areas

Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HSD11B2

References

PMID: 7859916 by Albiston A.L., et al. Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme.

PMID: 8530071 by Agarwal A.K., et al. Gene structure and chromosomal localization of the human HSD11K gene encoding the kidney (type 2) isozyme of 11 beta-hydroxysteroid dehydrogenase.