Histamine H2 receptor Antibodies

AND HRH2 ELISA kits, Histamine H2 receptor Proteins

Many biological assays use antibodies to detect Histamine H2 receptor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Histamine H2 receptor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Histamine H2 receptor antibodies...

We validate the specificity of these antibodies to Histamine H2 receptor by testing them on tissues known to express HRH2 positively and negatively. Browse below to find the HRH2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HRH2 Infographic by Boster Bio

All HRH2 Products

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Anti-Histamine H2 receptor HRH2 Antibody

Human, Mouse, Rat

IF, WB

$405
Cat # A05455
100ul

HRH2 (NM_022304) Human Over-expression Lysate

Human

$628
Cat # LS003274
100 µg

HRH2 Overview

Facts about Histamine H2 receptor.

HRH2 3D structure. Source: alphafold

Histamine H2 receptor (HRH2)

The H2 subclass of histamine receptors mediates gastric acid secretion. Also seems to modulate gastrointestinal motility and intestinal secretion.

Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).

Gene Information

Human
Gene Name:	HRH2
Uniprot:	P25021
Entrez:	3274

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

Gastric Receptor 1; Gastric receptor I; H2R; HH2R; Histamine H2 R; histamine H2 receptor; Histamine H2R; histamine receptor H2; HRH2

Molecular Weight

Mass (kDA):
40.098 kDA

Genomic Context


Human

Location:	5q35.2
Sequence:	5; NC_000005.10 (175657762..175710756)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Malignant Neoplasms
Stomach Neoplasms
Metaplasia
Neoplasms
Headache
Atrophy
Helicobacter Infections
Allergy
Angioedema
Urticaria
Gastritis
Malignant Neoplasm Of Stomach

Cholangiocarcinoma
Sclerosis
Bile Duct Neoplasms
Melanoma
Gastric Ulcer
Carcinoma

Pathways

Hypersensitivity
Cell Activation
Cell Proliferation
Ossification
Localization
Mast Cell Activation
Chemotaxis
Fermentation
Lipoxygenase Pathway
Cell Growth

Cell Chemotaxis
Pathogenesis
Gastric Acid Secretion
Acid Secretion
Secretion

PTMs

Phosphorylation

Dephosphorylation

Research Areas

GPCR
Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HRH2

References

PMID: 1714721 by Gantz I., et al. Molecular cloning of the human histamine H2 receptor.

PMID: 7755641 by Nishi T., et al. Identification of the promoter region of the human histamine H2- receptor gene.