Hps6 Antibodies

AND Hps6 ELISA kits, Hps6 Proteins

Many biological assays use antibodies to detect Hps6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Hps6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Hps6 antibodies...

We validate the specificity of these antibodies to Hps6 by testing them on tissues known to express Hps6 positively and negatively. Browse below to find the Hps6 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Hps6 Infographic by Boster Bio

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Hps6 Overview

Facts about Hermansky-Pudlak syndrome 6 protein homolog.

Hermansky-Pudlak syndrome 6 protein homolog (Hps6)

May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules (By similarity). Acts as cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes in the cell periphery to the perinuclear region.

Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos into lysosomes, for lysosome maturation and functioning (PubMed:25189619). .

Gene Information

Mouse
Gene Name:	Hps6
Uniprot:	Q8BLY7
Entrez:	20170

Family

Belongs to:

No superfamily

Alternative Names

FLJ22501; Hermansky-Pudlak syndrome 6 protein; Hermansky-Pudlak syndrome 6; Hermansky-Pudlak syndrome-6 protein (HPS6); MGC20522; RP11-302K17.1; Ru; Ruby-eye protein homolog

Molecular Weight

Mass (kDA):
87.341 kDA

Genomic Context


Mouse

Location:	19 C3\|19 38.75 cM
Sequence:	19;

Tissue Specificity

Widely expressed, with lowest expression in skeletal muscle.

Diseases

Hermanski-pudlak Syndrome
Albinism
Albinism, Oculocutaneous
Pulmonary Fibrosis
Fibrosis
Hemorrhage
Hypopigmentation Disorder
Crohn's Disease Of Large Bowel
Colitis
Hereditary Diseases
Melanoma
Mutation, Out-of-frame
Hypoxia

Bleeding Tendency
Severe Congenital Neutropenia
Lung Diseases, Interstitial
Storage Disease
Endoplasmic Reticulum Stress
Pneumonia
Pneumonia, Interstitial

Pathways

Pathogenesis
Secretion
Cell Proliferation
Melanocyte Differentiation
Pigmentation
Localization

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Hps6

References

PMID: 12548288 by Zhang Q., et al. Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6.

PMID: 19010779 by Salazar G., et al. Hermansky-Pudlak syndrome protein complexes associate with phosphatidylinositol 4-kinase type II alpha in neuronal and non- neuronal cells.