Serine protease hepsin Antibodies

AND HPN ELISA kits, Serine protease hepsin Proteins

Many biological assays use antibodies to detect Serine protease hepsin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Serine protease hepsin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Serine protease hepsin antibodies...

We validate the specificity of these antibodies to Serine protease hepsin by testing them on tissues known to express HPN positively and negatively. Browse below to find the HPN antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HPN Infographic by Boster Bio

All HPN Products

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Specificity

Applications

Price

Anti-HEPS HPN Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A02350
100ul

Anti-HPN Antibody (Center)

Human

$299
Cat # M02350
80 µl

Hepsin (HPN) (NM_182983) Human Over-expression Lysate

Human

$960
Cat # LS003249
100 µg

HPN Overview

Facts about Serine protease hepsin.

HPN 3D structure. Source: alphafold

Serine protease hepsin (HPN)

Serine protease that cleaves extracellular substrates, and leads to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837). Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933).

Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890).

Gene Information

Human
Gene Name:	HPN
Uniprot:	P05981
Entrez:	3249

Family

Belongs to:

peptidase S1 family

Alternative Names

EC 3.4.21; EC 3.4.21.106; Hepsin; HPN; serine protease hepsin catalytic chain; serine protease hepsin; TMPRSS1 ; TMPRSS1serine protease hepsin non-catalytic chain; Transmembrane protease serine 1; transmembrane protease, serine 1

Molecular Weight

Mass (kDA):
45.011 kDA

Genomic Context


Human

Location:	19q13.11
Sequence:	19; NC_000019.10 (35040506..35066573)

Tissue Specificity

Detected in liver and kidney.

Subcellular Localizations

Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein.

Diseases

Malignant Neoplasms
Short Bowel Syndrome
Neoplasms
Intestinal Diseases
Systemic Infection
Infective Disorder
Crohn Disease
Malabsorption Syndrome
Malnutrition
Liver Diseases
Intestinal Obstruction
Thrombosis

Gastrointestinal Diseases
Catheter Related Infection
Malignant Paraganglionic Neoplasm
Pain
Enteritis
Pseudo-obstruction

Pathways

Excretion
Intestinal Absorption
Pathogenesis
Aging
Secretion
Transport
Flight
Urea Cycle
Translation
Plasminogen Activation
Conjugation
Regeneration
Fatty Acid Oxidation

Bone Resorption
Protein Phosphorylation
Fatty Acid Elongation
Proteolysis
Immune Response
Hypersensitivity
Eating Behavior

PTMs

Ubiquitination
Demethylation
Phosphorylation

Hydroxylation
Deamination
Cleavage

Oxidation

Research Areas

Cancer
Prostate Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HPN

References

PMID: 2835076 by Leytus S.P., et al. A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells.

PMID: 1885621 by Tsuji A., et al. Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization.