This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Homeobox protein Hox-C10.
Human | |
---|---|
Gene Name: | HOXC10 |
Uniprot: | Q9NYD6 |
Entrez: | 3226 |
Belongs to: |
---|
Abd-B homeobox family |
homeo box C10; homeobox C10; Homeobox protein Hox-3I; homeobox protein Hox-C10; homeoprotein C10; HOX3I; MGC5259
Mass (kDA):
38.073 kDA
Human | |
---|---|
Location: | 12q13.13 |
Sequence: | 12; NC_000012.12 (53985146..53990279) |
Nucleus.
We'll be discussing Steven Boster’s life, his favorite HOXC10 markers and his hobbies in this article. We will discuss Steven Boster’s background and explain why he is the best HOXC10 marker maker. We'll then look at the best uses for this remarkable marker. Let's get started!
Researchers identified genes that were differentially regulated in the OSCC by HOXC10. KEGG analysis revealed HOXC10 correlated gene expression in genes that are enriched for Wnt signaling, RNA transportation, and mRNA surveillance. Knock-down mice showed a decrease in snail and an increase in E-cadherin. This also reversed the EMT-inducing action of Wnt10B.
The study showed that mice expressing HOXC10 had a lower glucose disposal rate than the controls, and that their BAT was not affected. In vivo, cold-induced browning of SubQ WAT was suppressed by HOXC10 in mice. Using this technique, researchers identified a specific subset of BAT cells that showed enhanced browning in response to cold. HOXC10 may therefore be useful in the treatment for obesity.
HOXC10 also promotes cell invasion and migration. A few studies have suggested that it may play a significant role in cancer metastasis. The researchers also found a decrease in migration ability for OSCC cells when HOXC10 was inhibited, suggesting that the protein is important to metastasis. HOXC10 is not only known to play a pro-metastasis function, but it also regulates the nuclear factor-kB pathway which is an important regulator for cancer metastasis.
Another study revealed that osteosarcoma cell movement is dependent on HOXC10. HOXC10 suppression led to a significant reduction in osteosarcoma cell proliferation. Over-expression of the gene resulted in a greater number of MG63 migratory cells through membranes. Despite the lack of evidence supporting this hypothesis the study suggests that HOXC10 could be an important target for osteosarcoma treatment.
The brown fat genes are suppressed by the protein HOXC10. Mutations in HOXC10 result in suppressive effects. Besides suppressive effects, HOXC10 also has a unique mechanism for suppressing brown fat gene expression in brown adipocytes. Its ability to bind DNA may help distinguish adipocytes from adipocytes in tissue.
PMID: 10835276 by de Stanchina E., et al. Selection of homeotic proteins for binding to a human DNA replication origin.
PMID: 9357979 by Flagiello D., et al. Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines.