Homeobox protein Hox-A5 Antibodies

Homeobox protein Hox-A5 (HOXA5)

Sequence-specific transcription factor that's part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter.

Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'. .

Gene Information

Human
Gene Name:	HOXA5
Uniprot:	P20719
Entrez:	3202

Family

Belongs to:
Antp homeobox family

Alternative Names

homeo box 1C; homeo box A5; homeobox A5; Homeobox protein Hox-1C; homeobox protein HOXA5; homeobox protein Hox-A5; HOX1; HOX1.3; HOX1CMGC9376

Molecular Weight

Mass (kDA):
29.345 kDA

Genomic Context

Human
Location:	7p15.2
Sequence:	7; NC_000007.14 (27141052..27143681, complement)

Subcellular Localizations

Nucleus.

Diseases

• Malignant Neoplasms
• Neoplasms
• Leukemia
• Malignant Neoplasm Of Breast
• Carcinoma
• Myeloid Leukemia
• Mammary Neoplasms
• Leukemia, Myelocytic, Acute
• Cell Transformation, Neoplastic
• Malignant Paraganglionic Neoplasm
• Chromosomal Translocation
• Carcinogenesis
• Leukemogenesis

• Tumor Angiogenesis
• Cytogenetic Abnormality
• Lung Diseases
• Embryonal Carcinoma
• Malignant Neoplasm Of Lung
• Acute Lymphocytic Leukemia
• Obesity

Pathways

• Methylation
• Dna Methylation
• Lung Development
• Pathogenesis
• Cell Differentiation
• Cell Proliferation
• Cell Death
• Angiogenesis
• Gene Silencing
• Cell Cycle
• Embryonic Morphogenesis
• Localization
• Histone Acetylation

• Segmentation
• Organ Morphogenesis
• Cell Cycle Arrest
• Lung Morphogenesis
• Mitosis
• Viral Replication
• Cell Migration

PTMs

• Methylation
• Demethylation

• Phosphorylation
• Reduction

• Acetylation

Research Areas

• Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HOXA5

Best Uses Of The HOXA5 Marker

If you are looking for a primary antibody that specifically targets HOXA5, you've come to the right place. Boster produces primary antibodies that are highly specific and have been validated for Western Blotting, Immunohistochemistry, and ELISA. Boster's antibodies have been highly cited and are well-established in the research community. They have been tested in many research methods, and have received excellent customer feedback.

HOXA5 Marker

HOXA5, a genetically derived tumor suppressor gene inhibits the abnormal proliferation GC cells. It has also been shown not to affect the expression of cMyc or Ki67 proteins. Studies in nude mice showed that HOXA5 inhibits GC cell proliferation. It is also known to suppress the expression of several other cancer genes.

Researchers have identified downstream processes of HOXA5 within the brain following birth. HOXA5 regulates Vglut1 (and Cadps2) genes. HOXA5 could also regulate development of cerebellum via maturation mossy fibril connections. HOXA5 also regulates Zic1, a Zinc Finger transcription factor involved in mossy-fiber development.

The HOXA5 marker colocalizes with Cbln1 and Adcy1 in the caudal portion of the trigeminal nucleus. In n = 3 brains that were hybridized with Hoxa5 or target genes in one ISH, colocalization was observed. These experiments revealed that HOXA5 correlated with target genes in a medial or lateral orientation.

PBX3

Boster Bio developed the HOXA5 mark. This marker is a monoclonal antibody that reacts with the Homeobox protein Hox-A5. This marker can be used in many biological assays. Boster Bio uses rabbits and mice as model organisms to test this marker. The main goal of this assay is to detect the protein in different tissue samples.

The HOXA5 gene regulates multiple processes that affect cellular transformation. The gene's expression is associated both with leukemogenesis (leukemia cell emergence) and overexpression. This gene is involved in many aspects and types of leukemia. Targeting it could be a promising therapeutic approach to many types of AML. Here are the Top Uses of the HOXA5 Marker

MEIS1

Researchers found that MLL fusion's leukemia-promoting effects were reconstructed by forced expression of the HOXA5 genes in a recent study. Moreover MEIS1 expression alone or in combination PBX3 caused a decrease of HOXA genes expression. These results suggest that targeting MEIS1/HOXA5 may offer new therapeutic approaches to various types leukemias.

The combined force expressions PBX3 & MEIS1 induced AML cells to produce the core transcriptome. This coexpression increased the expression levels of 160 genes, which included Hoxa genes. However, forced expression HOXA9 didn't cause upregulation of PBX3 and MEIS1.

The association with Pbx proteins is dependent on the functional domain of the Meis1 protein. It is vital for cell transformation as it regulates these gene expressions and disrupting this binding results in a decrease in their synergistic activity. Researchers can identify a target cell population by its three exons in the coding region. This gene is highly expressed in brain cells, and is often used in brain tumor models.

HOXA9

Researchers have developed a test that uses the HOXA9 gene to help identify cancer cells. Boster offers scientists the opportunity to submit their results to the company for a chance to receive product credits. Boster is open to scientists from all over the globe. The test can be used for specific samples, species, or applications. Boster scientists are sharing their results in an effort to improve their work.

The HOXA9 gene is found in both mice and rats. It is expressed in the human uterus where it plays an important role in embryonic responsiveness. Researchers have found that the gene is involved in several conditions that result in a decreased ability to implant a human embryo. Other human cancers that are linked to this gene include aplasticanemia, polycysticovarian syndrome, and other forms of cancer.

Researchers have identified numerous variants that can be used to analyze the gene. Kamimoto (K.), Adil (M. T.), Kong, W. Yang (X.), and Moreno Irusta (A. In addition to these, the HOXA9 gene is important in the study of cancer. There are many questions regarding how the HOXA9 genome is used.

HOXA9/PBX3

The HOXA5Marker is a highly efficient marker for human tumor research. The HOXA5 HOXA5 protein has a non-nuclease enzyme. Mutations of this enzyme include D917A, E1006A, D1227A, and D610A. These mutations resulted is the protein's loss of nuclease activitiy. As such, these proteins are useful for RNA-guided target sequence dependent delivery.

Listeria monocytogenes, the most prevalent bacterium in HOXA5, are the best. Other bacterial strains can also be useful. Leptotrichia Wadei F0279 is one of the most widespread strains. Opitutaceae B. bacterium DSM4847 is another.

HOXA9/MEIS1

The HOXA5 gene is important for lung development, maturation and function. The Hoxa5 genes is highly expressed in the mesenchyme, respiratory tract, and phrenicmotor neurons which innervate the diaphragm. Studies have shown that changes of Hoxa5 expression are associated pulmonary diseases. Here are some examples of the best uses of the HOXA5 marker.

HOXA5 can be involved in embryogenesis as well hematopoiesis. Numerous studies have examined the role of HOXA5 for cervical cancer. Pei et al. Pei et al. found that patients who are more likely to survive than those who are less regulated by HOXA5 have a lower chance of survival. Pei and coworkers also reported that low HOXA5 levels were associated with poor differentiation and survival in cervical cancer. HOXA5 inhibits invasion and proliferation and induces apoptosis via AKT.

Another study demonstrated that TAMR-like properties can be induced by elevated HOXA5 transcription. In fact, an increasing body of evidence indicates that TAMR breast cancers are more aggressive and self-renewing than the conventional type. Moreover, BCSC activation depends on an elevated HOXA5 level. This is necessary for enhanced formation and activation of spheroids enriched from BCSCs.

HOXA9 and nothing else

HOXA9 has a critical role in cell signaling through interaction with other transcription factor. This interaction involves ATF-2/Jun, HMG-I(Y), and p300. These interactions can be dynamic and change depending on physiological state. HOXA9 is a member the family homeobox genes. It is essential for the proper regulation of cell shape, adhesion, and signaling.

NPMc+-expressing PBX3 cells have a higher level of HOXA9 expression. The decrease of PBX3 in leukemia cells causes the cells to enter apoptosis. HOXA9, however, is a co-factor necessary for PBX3 transcription. Hence, HOXA9 as well as PBX3 could play important roles in the progression leukemia.

HOXA9 plays a vital role in vascular development. It helps in the formation endothelial tubules during angiogenesis. It is also responsible for regulating the commitment of adult precursor cells to the endothelial cell lineage. However, HOXA9 is involved in a number of post-translational modifications that are associated with vascular defects. TNF alpha stimulates PRMT5 mediated methylation HOXA9 at Arg140. It is a key regulator of the induction specific ELAMs.