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- Table of Contents
Facts about Protein Hook homolog 2.
Contributes to the establishment and maintenance of centrosome function. May be the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones.
Human | |
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Gene Name: | HOOK2 |
Uniprot: | Q96ED9 |
Entrez: | 29911 |
Belongs to: |
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hook family |
FLJ26218; hHK2; HK2h-hook2; hook homolog 2 (Drosophila); protein Hook homolog 2
Mass (kDA):
83.207 kDA
Human | |
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Location: | 19p13.13 |
Sequence: | 19; NC_000019.10 (12763002..12778484, complement) |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton. Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome (PubMed:17540036). Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosome, or mitochondria (PubMed:17540036). Often found in close association with microtubules (PubMed:17540036). Localizes to the manchette in elongating spermatids (By similarity).
PMID: 9927460 by Kraemer H., et al. Genetic analysis of hook, a gene required for endocytic trafficking in Drosophila.
PMID: 11238449 by Walenta J.H., et al. The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins.