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- Table of Contents
4 Citations 10 Q&As
25 Citations 16 Q&As
8 Citations 4 Q&As
19 Citations 5 Q&As
1 Citations
Facts about Heme oxygenase 1.
Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
Human | |
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Gene Name: | HMOX1 |
Uniprot: | P09601 |
Entrez: | 3162 |
Belongs to: |
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heme oxygenase family |
bK286B10; EC 1.14.99.3; heat shock protein, 32-kD; heme oxygenase (decycling) 1; HMOX1; HO; HO1; HO-1; HO-1heme oxygenase 1; HSP32
Mass (kDA):
32.819 kDA
Human | |
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Location: | 22q12.3 |
Sequence: | 22; NC_000022.11 (35381096..35394207) |
Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
Microsome. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
PMID: 3345742 by Yoshida T., et al. Human heme oxygenase cDNA and induction of its mRNA by hemin.
PMID: 2911585 by Keyse S.M., et al. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.
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