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- Table of Contents
Facts about HLA class II histocompatibility antigen, DQ beta 1 chain.
The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
Human | |
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Gene Name: | HLA-DQB1 |
Uniprot: | P01920 |
Entrez: | 3119 |
Belongs to: |
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MHC class II family |
CELIAC1; DC1; HLA class II histocompatibility antigen, DQ beta 1 chain; HLA-DQB; IDDM1; LB-E12; MB1; MHC class II antigen DQB1; MHC class II antigen HLA-DQ-beta-1; MHC class II DQ beta chain; MHC class II HLA-DQ beta glycoprotein; MT1
Mass (kDA):
29.991 kDA
Human | |
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Location: | 6p21.32 |
Sequence: | 6; NC_000006.12 (32659467..32666657, complement) |
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
PMID: 6415003 by Larhammar D., et al. Molecular analysis of human class II transplantation antigens and their genes.
PMID: 6954511 by Larhammar D., et al. Complete amino acid sequence of an HLA-DR antigen-like beta chain as predicted from the nucleotide sequence: similarities with immunoglobulins and HLA-A, -B, and -C antigens.