Protein HIRA Antibodies

AND HIRA ELISA kits, Protein HIRA Proteins

Many biological assays use antibodies to detect Protein HIRA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein HIRA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein HIRA antibodies...

We validate the specificity of these antibodies to Protein HIRA by testing them on tissues known to express HIRA positively and negatively. Browse below to find the HIRA antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HIRA Infographic by Boster Bio

All HIRA Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Phospho HIRA (Thr555) Antibody

7 Q&As

Human, Mouse

ELISA, IF, IHC-P, ICC, WB

$335
Cat # P03101
100ul

Anti-Phospho-HIRA (T555) Antibody

Human, Mouse

ELISA, IF, IHC

$380
Cat # A03101T555
100ul

Anti-Protein HIRA HIRA Antibody

Human, Mouse

ELISA, IHC

$380
Cat # A03101
100ul

Anti-HIRA Rabbit Polyclonal Antibody

Human, Mouse, Rat

$477
Cat # A03101-1
100 µl

Anti-HIRA Rabbit Monoclonal Antibody

Human

Flow Cytometry, IP, IF, ICC, WB

$370
Cat # M03101
100 μl/vial

HIRA Overview

Facts about Protein HIRA.

HIRA 3D structure. Source: alphafold

Protein HIRA (HIRA)

Cooperates with ASF1A to market replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle.

Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. .

Gene Information

Human
Gene Name:	HIRA
Uniprot:	P54198
Entrez:	7290

Family

Belongs to:

WD repeat HIR1 family

Alternative Names

DGCR1DiGeorge critical region gene 1; HIR (histone cell cycle regulation defective) homolog A (S. cerevisiae); HIR histone cell cycle regulation defective homolog A (S. cerevisiae); HIR; TUP1; TUP1-like enhancer of split protein 1; TUPLE1protein HIRA

Molecular Weight

Mass (kDA):
111.835 kDA

Genomic Context


Human

Location:	22q11.21
Sequence:	22; NC_000022.11 (19330698..19431733, complement)

Tissue Specificity

Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta.

Subcellular Localizations

Nucleus. Nucleus, PML body. Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.

Diseases

Digeorge Syndrome
Haploinsufficiency
Congenital Abnormality
Congenital Heart Defects
Neoplasms
Malignant Neoplasms
Congenital Heart Disease
Crest Syndrome
Osteoporosis
Heart Diseases
Developmental Disabilities
Craniofacial Abnormalities
Fracture

Cytogenetic Abnormality
Heart Septal Defects
Acute Promyelocytic Leukemia
Cleft Palate
Ventricular Septal Defects
Hereditary Diseases
Osteoporotic Fractures

Interacting Proteins

ASF1A
ASF1B
UBN1

Pathways

Chromatin Assembly
Nucleosome Assembly
Cell Cycle
Dna Replication
Senescence
Fertilization
Chromatin Remodeling
Localization
Cellular Senescence
S Phase
Gene Silencing
Mitosis
Methylation

Aging
Chromatin Organization
Dna Repair
Gastrulation
Metaphase
Histone Modification
Cell Division

PTMs

Phosphorylation
Acetylation
Methylation

Demethylation
Deacetylation
Phosphorothioation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HIRA

References

PMID: 7633437 by Lamour V., et al. A human homolog of the S. cerevisiae HIR1 and HIR2 transcriptional repressors cloned from the DiGeorge syndrome critical region.

PMID: 8681138 by Lorain S., et al. Structural organization of the WD repeat protein-encoding gene HIRA in the DiGeorge syndrome critical region of human chromosome 22.