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- Table of Contents
Facts about Huntingtin-interacting protein 1-related protein.
May act through the ENTH domain name to promote cell survival by stabilizing receptor tyrosine kinases after ligand-induced endocytosis. .
Human | |
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Gene Name: | HIP1R |
Uniprot: | O75146 |
Entrez: | 9026 |
Belongs to: |
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SLA2 family |
FLJ14000; HIP-12; HIP12HIP1-related protein; HIP3; huntingtin interacting protein 1 related; huntingtin interacting protein 12; Huntingtin-interacting protein 12; huntingtin-interacting protein 1-related protein; ILWEQ; KIAA0655FLJ27022; MGC47513
Mass (kDA):
119.388 kDA
Human | |
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Location: | 12q24.31 |
Sequence: | 12; NC_000012.12 (122834498..122862961) |
Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.
Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
PMID: 11063258 by Chopra V.S., et al. HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin.
PMID: 9852681 by Seki N., et al. Cloning, expression analysis, and chromosomal localization of HIP1R, an isolog of huntingtin interacting protein (HIP1).