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HIF1A Antibodies
AND HIF1A ELISA kits, HIF1A Proteins
Many biological assays use antibodies to detect HIF1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HIF1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HIF1A antibodies...
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HIF1A Infographic by Boster Bio
All HIF1A Products
Product
Figures
Specificity
Applications
Price
Anti-HIF-1-alpha/HIF1A Antibody Picoband®
74 Citations 18 Q&As
Human, Mouse, Rat
IHC, WB
$370
Cat # PB9253
100 μg/vial
Cat # PB9253
100 μg/vial
Anti-HIF-1 alpha (HIF1A) Rabbit Monoclonal Antibody, Clone#RM242
11 Citations 16 Q&As
Human
IHC, WB
$431
Cat # M00013-1
100ul
Cat # M00013-1
100ul
Anti-HIF-1 alpha/HIF1A Antibody Picoband®
11 Citations 16 Q&As
Human
ELISA, WB
$370
Cat # A00013-1
100 μg/vial
Cat # A00013-1
100 μg/vial
Anti-HIF-alpha HIF1A Monoclonal Antibody
5 Citations
Human, Monkey, Mouse
ELISA, IF, IHC, WB
$380
Cat # M00013-2
100ul
Cat # M00013-2
100ul
Anti-HIF-1 alpha/HIF1A Antibody Picoband®
28 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00013-3
100 μg/vial
Cat # A00013-3
100 μg/vial
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00013-3
100 μl/vial
Cat # M00013-3
100 μl/vial
Human, Mouse, Rat
IF, ICC, WB
$370
Cat # M00013-4
100 µl/vial
Cat # M00013-4
100 µl/vial
HIF1A Overview
Facts about Hypoxia-inducible factor 1-alpha.
Hypoxia-inducible factor 1-alpha (HIF1A)
Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen consumption or alleviate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.
Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' inside the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators like CREBBP and EP300.
Gene Information
| Human | |
|---|---|
| Gene Name: | HIF1A |
| Uniprot: | Q16665 |
| Entrez: | 3091 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AINT; HIF-1 alpha; HIF1A; ARNT interacting protein; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; BHLHE78; Class E basic helix-loop-helix protein 78; H1alpha67; HIF 1A; HIF1 alpha; HIF-1 alpha; HIF1; HIF1A; HIF-1a; HIF-1alpha; HIF-1-alpha; HIF1-alpha; hypoxia inducible factor 1 alpha subunit, hypoxia inducible factor 1 subunit alpha; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1-alpha; Member of PAS protein 1; member of PAS superfamily 1; MOP1; PAS domain-containing protein 8; PASD8
Molecular Weight
Mass (kDA):
92.67 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q23.2 |
| Sequence: | 14; NC_000014.9 (61695513..61748259) |
Tissue Specificity
Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors. A higher level expression seen in pituitary tumors as compared to the pituitary gland.
Subcellular Localizations
Cytoplasm. Nucleus. Nucleus speckle. Colocalizes with HIF3A in the nucleus and speckles (By similarity). Cytoplasmic in normoxia, nuclear translocation in response to hypoxia (PubMed:9822602).
Diseases
- Hypoxia
- Neoplasms
- Malignant Neoplasms
- Tumor Angiogenesis
- Anoxia
- Pathologic Neovascularization
- Carcinoma
- Neoplasm Metastasis
- Von Hippel-lindau Syndrome
- Ischemia
- Inflammation
- Mammary Neoplasms
Interacting Proteins
- AR
- ARNT
- ARRB1
- BHLHE41
- Bhlhe41
- CBX4
- CREBBP
- CTNNB1
- E2f7
- EAF2
Pathways
- Angiogenesis
- Response To Hypoxia
- Cell Proliferation
- Secretion
- Glycolysis
- Cell Death
- Pathogenesis
- Cell Growth
- Oxygen Homeostasis
- Translation
- Cell Cycle
- Localization
- Transport
PTMs
- Phosphorylation
- Hydroxylation
- Ubiquitination
- Cleavage
- Acetylation
- Methylation
- Oxidation
- Reduction
- Dephosphorylation
- Deacetylation
Research Areas
- Adaptive Immunity
- Angiogenesis
- Autophagy
- Cancer
- Cellular Markers
- Chromatin Research
- Cytokine Research
- Hypoxia
- Hypoxia Signaling
- Immunology
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HIF1A
bosterbio.com/bosterbio-gene-info-cards/HIF1A
References
PMID: 7539918 by Wang G.L., et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
PMID: 9079689 by Hogenesch J.B., et al. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.
100 Publications of Boster HIF1A Antibodies & ELISA Kits
- PubMed ID: 10.7150/thno.51144, AhR activation attenuates calcium oxalate nephrocalcinosis by diminishing M1 mac...
- PubMed ID: 10.3980/j.issn.2222-3959.2011.01.09, Effect of erythropoietin on the expression of HIF-1 and iNOS in retina in chroni...
- PubMed ID: 10.3969/j.issn.1673-5374.2013.04.005, Expression of hypoxia-inducible factor 1 alpha and oligodendrocyte lineage gene-...
- PubMed ID: 10.3892/or_00000833, Hypoxia-inducible factor-1α modulates the down-regulation of the homeodomain pr...
- PubMed ID: 10.3892/ol.2014.2607, Nitric oxide signaling pathway activation inhibits the immune escape of pancreat...
- PubMed ID: 10.3892/mmr.2014.2859, HIF‑1 signaling pathway involving iNOS, COX‑2 and caspase‑9 mediates the n...
- PubMed ID: 10.3892/etm.2016.3030, Role of hypoxia-inducible factor-1α in pathogenesis and disease evaluation of u...
- PubMed ID: 10.3892/etm.2011.389, Improved radiosensitizing effect of the combination of etanidazole and paclitaxe...
- PubMed ID: 10.3748/wjg.v21.i7.2191, Semaphorin 4D and hypoxia-inducible factor-1α overexpression is related to prog...
- PubMed ID: 10.3748/wjg.v17.i14.1915, Oxidative stress and hypoxia-induced factor 1α expression in gastric ischemia
- PubMed ID: 10.3727/096368911X566181, Bone Marrow Mesenchymal Stem Cells in a Three-Dimensional Gelatin Sponge Scaffol...
- PubMed ID: 10.3389/fphar.2021.648107, Curcumin Derivative Cur20 Attenuated Cerebral Ischemic Injury by Antioxidant Eff...
- PubMed ID: 10.3233/CBM-150474, Expression of BNIP3 and its correlations to hypoxia-induced autophagy and clinic...
- PubMed ID: 10.3233/BME-2011-0674, Analysis of neovascularization after implanting porous silk fibroin films in rat...
- PubMed ID: 10.3109/03008200902855891, Effect of Negative Pressure on Human Bone Marrow Mesenchymal Stem Cells In Vitro
- PubMed ID: 10.1902/jop.2010.100610, The Role of Psychologic Stress‐Induced Hypoxia‐Inducible Factor‐1α in Rat...
- PubMed ID: 10.18632/oncotarget.9899, CD47 deficiency in tumor stroma promotes tumor progression by enhancing angiogen...
- PubMed ID: 10.1590/1414-431X20142910, Putative role of ischemic postconditioning in a rat model of limb ischemia and r...
- PubMed ID: 10.12659/MSM.900354, Expression and Correlation of Hypoxia-Inducible Factor-1α (HIF-1α) with Pulmon...
- PubMed ID: 10.1186/s13287-020-02112-9, Intraperitoneal injection of Desferal® alleviated the age-related bone loss and...
- PubMed ID: 10.1186/s13046-016-0399-7, Hyperthermia induced HIF-1a expression of lung cancer through AKT and ERK signal...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page