HIC1 Antibodies

AND HIC1 ELISA kits, HIC1 Proteins

Many biological assays use antibodies to detect HIC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HIC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HIC1 antibodies...

We validate the specificity of these antibodies to HIC1 by testing them on tissues known to express HIC1 positively and negatively. Browse below to find the HIC1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HIC1 Infographic by Boster Bio

All HIC1 Products

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Specificity

Applications

Price

Anti-African clawed frog Hic1 Antibody

African clawed frog

$470
Cat # DZ02540
200 μl/vial

Anti-HIC1 Antibody

Human, Rat

$405
Cat # A02540
100ul

HIC1 Overview

Facts about Hypermethylated in cancer 1 protein.

HIC1 3D structure. Source: alphafold

Hypermethylated in cancer 1 protein (HIC1)

Transcriptional repressor. May act as a tumor suppressor.

May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses.

Gene Information

Human
Gene Name:	HIC1
Uniprot:	Q14526
Entrez:	3090

Family

Belongs to:

krueppel C2H2-type zinc-finger protein family

Alternative Names

hic-1; hypermethylated in cancer 1; ZBTB29hypermethylated in cancer 1 protein; Zinc finger and BTB domain-containing protein 29; ZNF901

Molecular Weight

Mass (kDA):
76.508 kDA

Genomic Context


Human

Location:	17p13.3
Sequence:	17; NC_000017.11 (2055103..2063241)

Tissue Specificity

Ubiquitously expressed with highest levels found in lung, colon, prostate, thymus, testis and ovary. Expression is absent or decreased in many tumor cells.

Subcellular Localizations

Nucleus.

Diseases

Neoplasms
Malignant Neoplasms
Carcinoma
Cell Transformation, Neoplastic
Malignant Paraganglionic Neoplasm
Colorectal Cancer
Colorectal Neoplasms
Mammary Neoplasms
Malignant Neoplasm Of Breast
Carcinogenesis
Microsatellite Instability
Leukemia

Medulloblastoma
Leukemia, Myelocytic, Acute
Adenocarcinoma
Malignant Tumor Of Colon
Myeloid Leukemia
Brain Neoplasms
Polyps

Interacting Proteins

ARID1A
CTBP1
Ctbp1
CTBP2
Ctbp2

TCF7L2

Pathways

Methylation
Dna Methylation
Pathogenesis
Dna Hypermethylation
Gene Silencing
Cell Cycle
Demethylation
Cell Proliferation
Localization
Rna Interference
Dna Hypomethylation
Aging
Dna Demethylation

Regulation Of Gene Expression
Oncogenesis
Dna Repair
Senescence
Drug Resistance
Mismatch Repair
Angiogenesis

PTMs

Methylation
Demethylation
Deacetylation
Acetylation

Sumoylation
Phosphorylation
Reduction
Glycosylation

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HIC1

References

PMID: 7585125 by Wales M.M., et al. p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3.

PMID: 10611298 by Deltour S., et al. Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B.