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- Table of Contents
Facts about Hepatocyte growth factor activator.
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Human | |
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Gene Name: | HGFAC |
Uniprot: | Q04756 |
Entrez: | 3083 |
Belongs to: |
---|
peptidase S1 family |
HGF Activator; HGFA; Hgfac
Mass (kDA):
70.682 kDA
Human | |
---|---|
Location: | 4p16.3 |
Sequence: | 4; NC_000004.12 (3441968..3449486) |
Liver.
Secreted. Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.
PMID: 7683665 by Miyazawa K., et al. Molecular cloning and sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII.
PMID: 9874200 by Miyazawa K., et al. Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene -- phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue- type plasminogen activator.