HERC2 Antibodies

AND HERC2 ELISA kits, HERC2 Proteins

Many biological assays use antibodies to detect HERC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HERC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HERC2 antibodies...

We validate the specificity of these antibodies to HERC2 by testing them on tissues known to express HERC2 positively and negatively. Browse below to find the HERC2 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HERC2 Infographic by Boster Bio

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HERC2 Overview

Facts about E3 ubiquitin-protein ligase HERC2.

E3 ubiquitin-protein ligase HERC2 (HERC2)

E3 ubiquitin-protein ligase that regulates ubiquitin- dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 boosting DNA damage-induced formation of'Lys-63'-linked ubiquitin chains.

Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels.

Gene Information

Human
Gene Name:	HERC2
Uniprot:	O95714
Entrez:	8924

Family

Belongs to:

No superfamily

Alternative Names

D15F37S1; DKFZp547P028; E3 ubiquitin-protein ligase HERC2; EC 6.3.2; EC 6.3.2.-; HECT domain and RCC1-like domain-containing protein 2; hect domain and RLD 2; jdf2; KIAA0393; p528; probable E3 ubiquitin-protein ligase HERC2; SHEP1

Molecular Weight

Mass (kDA):
527.228 kDA

Genomic Context


Human

Location:	15q13.1
Sequence:	15; NC_000015.10 (28111040..28322179, complement)

Subcellular Localizations

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Recruited to sites of DNA damage in response to ionizing radiation (IR) via its interaction with RNF8. May loose association with centrosomes during mitosis.

Diseases

Angelman Syndrome
Prader-willi Syndrome
Malignant Neoplasms
Albinism, Oculocutaneous
Albinism
Autistic Disorder
Oculocutaneous Albinism Type 2
Melanoma
Ulcer
Dysequilibrium Syndrome
Skin Neoplasms
Inflammatory Bowel Diseases

Crohn Disease
Colitis
Ulcerative Colitis
Autoimmunity
Ataxia
Neuromuscular Diseases
Intestinal Diseases

Interacting Proteins

Pathways

Pigmentation
Dna Repair
Eye Pigmentation
Dna Methylation
Proteolysis
Methylation
Pathogenesis
Transposition
Cell-cell Signaling
Sex Determination
Localization
Reflex
Double-strand Break Repair

Maternal Behavior
Cytoskeleton Organization
Dna Replication
Translation
Cell Death
Cell Cycle
S Phase

PTMs

Phosphorylation
Ubiquitination

Sumoylation
Acetylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HERC2

References

PMID: 9949213 by Ji Y., et al. The ancestral gene for transcribed, low-copy repeats in the Prader- Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities.

PMID: 10720573 by Ji Y., et al. Structure of the highly conserved HERC2 gene and of multiple partially duplicated paralogs in human.