HDGF Antibodies

Hepatoma-derived growth factor (HDGF)

Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor.

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Gene Information

Human
Gene Name:	HDGF
Uniprot:	P51858
Entrez:	3068

Family

Belongs to:
HDGF family

Alternative Names

FLJ96580; HDGF; hepatoma-derived growth factor (high-mobility group protein 1-like); hepatoma-derived growth factor; High mobility group protein 1-like 2; HMG-1L2; HMG1L2DKFZp686J1764; HuHGF

Molecular Weight

Mass (kDA):
26.788 kDA

Genomic Context

Human
Location:	1q23.1
Sequence:	1; NC_000001.11 (156742107..156752448, complement)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

[Isoform 1]: Nucleus. Cytoplasm. Secreted, extracellular exosome. Secreted by exosomes and is located inside the exosome (PubMed:27926477). May also be secreted as free protein via an as yet unknown pathway (PubMed:27926477).; [Isoform 2]: Nucleus. Cytoplasm. Secreted, extracellular exosome. Secreted by exosomes and is located on the outer exosome surface.; [Isoform 3]: Nucleus. Cytoplasm. Secreted, extracellular exosome. Secreted by exosomes and is located on the outer exosome surface.

Diseases

• Malignant Neoplasms
• Neoplasms
• Liver Carcinoma
• Carcinoma
• Cell Invasion
• Cell Transformation, Neoplastic
• Malignant Neoplasm Of Lung
• Liver Neoplasms
• Non-small Cell Lung Carcinoma
• Tumor Angiogenesis
• Malignant Paraganglionic Neoplasm
• Lung Neoplasms

• Adenocarcinoma
• Neoplasm Metastasis
• Neoplasm Invasiveness
• Carcinogenesis
• Malignant Squamous Cell Neoplasm
• Pathologic Neovascularization
• Hepatocarcinogenesis

Pathways

• Cell Proliferation
• Cell Growth
• Localization
• Angiogenesis
• Secretion
• Cell Migration
• Pathogenesis
• Liver Development
• Hepatocyte Proliferation
• Cell Cycle
• Cell Differentiation
• Regeneration
• Chromatin Remodeling

• Organ Development
• Tube Formation
• Mitosis
• Cell Death
• Rna Interference
• Kidney Development
• Hepatocyte Differentiation

PTMs

• Phosphorylation
• Dephosphorylation

• Phosphorothioation
• Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HDGF

Boster Bio's Best Uses Of The HDGF Marker

If you're considering using HDGF in your research, you'll want to learn more about Boster Bio's Anti-Hepatocyte Growth Factor (HGF) Marker. This biomarker is able to detect the presence of HDGF and its strong growth-stimulating properties. It is also available as primary antibodies that have high affinity for HDGF. To know more about HDGF, continue reading!

Boster Bio's Anti-Hepatocyte Growth Efficacy Factor HGF Marker

The aim of this study was to examine human proximal tubular cellular cells for the determination of HepG2 levels. Human kidney proximal tubular cells were obtained from the Cell Bank of Type Culture Collection of the Chinese Academy of Sciences in Shanghai, China. Antibodies against a SMA, JAK2 and STAT3 were obtained from Wuhan Boster Biological Technology, Ltd.

The results revealed that HGF helps stem cells resist apoptosis. The study was published in two scientific journals: Acta Biochim Biophys Sin (Shanghai) and J Cell Mol Med. Wen Q and colleagues studied the effects of HGF on stem cells as well as the role of the hepatic protein in bone growth and repair. Researchers found that HGF exposed hBMSCs displayed higher expression of mitochondrial related proteins dynamics, catalase and oxidative.

HGF is essential for liver health and the pathophysiology that causes IR. It plays a key part in the mother's b-cell adadaptation and is a potential therapeutic target. HGF also reduces hepatic sugar output. HGF regulates the metabolism of glucose in the liver and regulates inflammatory responses. The higher levels of HGF in blood serum are linked with obesity.

It detects HDGF

Boster Bio has developed antibodies that detect HDGF in biological samples. They can be used to identify the protein. This protein is secreted through exosomes. It is present in three isoforms. It is also possible to be free in certain cases. In this test, Boster Bio uses rabbit and mouse for the production of antibodies to HDGF.

The anti-HDGFRP2 HDGFL2 antibody (catalog # PA2267) was created against a synthetic protein that contains 18 amino acid sequences which include the human HDGF gene. This antibody recognizes HDGF in a region that spans amino acids fifty-one hundred. While the antibody isn't specific for any particular species or application, it is effective in WB as well as IHC applications. The boster bio anti-HDGFRP2 antibody is compatible with the majority of tissue types and can be stored between -20 and 80 degrees C for up to an entire year.

High-affinity antibody, also referred to as HEpGF are an essential element of a successful ELISA. They allow researchers to discover proteins of interest with a very low background level and high specificity. Boster Bio strives to provide excellent customer service and stands behind its products. All Boster Bio antibodies are protected by a 100 percent Boster Quality Guarantee, and the company actively expands its product lines each month.

It has strong growth stimulating activity

Boster Bio's HDGF marker exhibits the highest degree of growth stimulating properties, proving that HDGF is present in cells that have the lowest levels of expression. The purified HDGF is available as a protein in the form of a crude. This protein was partially purified by BioRex 70 chromatography. The purified protein was stained with antibody and protein. HDGF binds with DNA and stimulates cell growth.

This allows researchers to determine which cells have the most of this protein. In addition to its growth-promoting activity, HDGF has several other functions. It is thought to be an angiogenic agent, and could help repair respiratory system damages. Studies have revealed that HDGF could be involved in the development of organs. It could also act as an anti-apoptotic agent.

In addition to its growth-stimulating activity HDGF also triggers the AKT/HIF-1a-mediated signaling pathway and influences VEGF expression in oral cancer cells. It is useful for diagnosing and drug development. Boster Bio's HDGF marker is extremely efficient in stimulating growth in different kinds of cancer. It has a great chance to be used as a therapeutic agent.

It is available in high-affinity prima antibodies

High-affinity primary antibodies now have an additional marker that can identify HDGF. This marker is known as bosterin molecular. The HDGF protein has the 240 residues of a consensus sequence that includes PWWP, a bipartite nuclear location motif and a bipartite nuclear binding motif. This antibody recognizes HDGF expression by immunohistochemistry, a technique that allows researchers to monitor HDGF levels in a cell culture.

This antibody can recognize the HDGF protein on tumor cells. It has been demonstrated that HDGF expression is higher in hyperproliferative tissues, particularly tumors. Boster Bio has high-affinity antibodies against this protein. These antibodies may also come from other sources. Among these techniques is immunohistochemistry, which involves selecting a member of the HDGF family that is highly expressed. The enzymatic tags are then used to measure the intensity of binding. The intensity is multiplied by the percentage of cells that have been stained positively with HDGF.

Another method of detecting HDGF is the use of siNA, which is a small inhibitory nucleic acid or DNA molecule that has been engineered to express siRNA. HDGF expression is the most popular siRNA. Both of these strategies are extremely effective in the detection of HDGF. The new technology allows doctors to concentrate on HDGF and other hyperproliferative cells-mediated diseases.

It is validated using WB, IHC

Boster Bio recently validated the HDGF marker using the purified protein. It is a hepatoma-derived growth factor, believed to play a key role in tumor initiation as well as cell signaling. Boster Bio validated this marker on WB and IHC/IFC. This confirms that it's a top-quality exact antibody to HDGF.

Its polynucleotide that is akin to HDGF can be useful in studies of cell-to-cell communication and dendritic cell function. Polynucleotides are also able to identify DEC ligands, and help in targeting dendritic cells with antigens and offer tolerance even when dendritic cells have stopped responding. The HDGF marker in WB, IHC, and ICC is a highly-sensitive antibody that allows researchers to examine the expression of HDGF in different tissues.

The HDGF marker is validated using Boster Bio validation of the HDGF gene on WB, IHC, and ICC. This antibody is an immunohistochemical reaction to detect HDGF. The HDGF gene is present in many tissues which include the brain, fetal liver and spleen. It is also more or less expressed in the lymph node and bone marrow.

It is confirmed by ICC

The Boster Bio HDGF Marker is validate on ICC and IP. This antibody is extremely specific to the Human species. This antibody is a suitable option for research due to its high affinity. This antibody is available in a 100ul Liquid and is highly suggested for use in IHC. It is also validated on ELISA. It's available in different sizes. If you're searching for a specific antibody for a certain tissue type, you can purchase an antibody from Boster Bio.

It is also available as a set of reagents

The kit contains all the reagents required conduct a specific test known as ELISA. ELISA is a plate-based experiment that detects the presence of molecules through the use of antibodies linked to enzymes. ELISAs are available in various designs, each of which employs an individual principle of antibody-antigen interaction. A Picokine(tm) ELISA kit contains high affinity antibodies that identify native forms of proteins. Boster's ELISA kits are tested against similar immunogenic proteins as well as superfamilies.