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Histone deacetylase 4 Antibodies
AND HDAC4 ELISA kits, Histone deacetylase 4 Proteins
Many biological assays use antibodies to detect Histone deacetylase 4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Histone deacetylase 4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Histone deacetylase 4 antibodies...
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HDAC4 Infographic by Boster Bio
All HDAC4 Products
Product
Figures
Specificity
Applications
Price
Anti-HDAC4 Antibody Picoband®
3 Citations 1 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00971-1
100 μg/vial
Cat # A00971-1
100 μg/vial
Anti-HDAC4/Histone Deacetylase 4 Rabbit Monoclonal Antibody
1 Citations 4 Q&As
Human
IF, ICC, WB
$370
Cat # M00971
100 μl
Cat # M00971
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1264
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1264
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2423
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2423
1 kit, containing two 96-well plates and all necessary reagents
HDAC4 Overview
Facts about Histone deacetylase 4.
Histone deacetylase 4 (HDAC4)
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays a significant role in transcriptional regulation, cell cycle progression and developmental events.
Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation through its interaction with the myocyte enhancer factors like MEF2A, MEF2C and MEF2D.
Gene Information
| Human | |
|---|---|
| Gene Name: | HDAC4 |
| Uniprot: | P56524 |
| Entrez: | 9759 |
Family
| Belongs to: |
|---|
| histone deacetylase family |
Alternative Names
HA6116; HD4EC 3.5.1.98; HDAC4; HDAC-A; HDACABDMR; Histone Deacetylase 4; histone deacetylase A; KIAA0288AHO3
Molecular Weight
Mass (kDA):
119.04 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q37.3 |
| Sequence: | 2; NC_000002.12 (239048168..239401649, complement) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. Interaction with SIK3 leads to HDAC4 retention in the cytoplasm (By similarity).
Diseases
- Malignant Neoplasms
- Neoplasms
- Hypertrophy
- Traditional Serrated Adenoma
- Carcinoma
- Leukemia
- Cardiac Hypertrophy
- Neurodegenerative Disorders
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Inflammation
Interacting Proteins
- ANKRA2
- AR
- ATF2
- BCL6
- BRMS1
- CDR2
- EFEMP2
- GOLGA2
- KRT31
- KRT38
Pathways
- Localization
- Histone Acetylation
- Cell Cycle
- Nuclear Export
- Histone Deacetylation
- Cell Growth
- Cell Death
- Cell Proliferation
- Cell Differentiation
- Rna Interference
- Pathogenesis
- Methylation
- Nuclear Import
PTMs
- Acetylation
- Phosphorylation
- Deacetylation
- Sumoylation
- Methylation
- Dephosphorylation
Research Areas
- Breast Cancer
- Cancer
- Cell Cycle and Replication
- Chromatin Research
- Epigenetics
- Phospho-Specific
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HDAC4
bosterbio.com/bosterbio-gene-info-cards/HDAC4
References
PMID: 10220385 by Grozinger C.M., et al. Three proteins define a class of human histone deacetylases related to yeast Hda1p.
PMID: 9179496 by Ohara O., et al. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins.
3 Publications of Boster Histone deacetylase 4 Antibodies & ELISA Kits
- PubMed ID: 10.3727/096504016X14732510786564, Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppr...
- PubMed ID: 10.1016/j.jcmgh.2021.05.020, Wilson disease: intersecting DNA methylation and histone acetylation regulation ...
- PubMed ID: 26473953, Arsenic trioxide reduces global histone H4 acetylation at lysine 16 through dire...
*More publications can be found for each product on its corresponding product page