HCST Antibodies

AND HCST ELISA kits, HCST Proteins

Many biological assays use antibodies to detect HCST, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HCST in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HCST antibodies...

We validate the specificity of these antibodies to HCST by testing them on tissues known to express HCST positively and negatively. Browse below to find the HCST antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HCST Infographic by Boster Bio

All HCST Products

Product

Figures

Specificity

Applications

Price

HCST (NM_001007469) Human Recombinant Protein

$1249
Cat # PROTQ9UBK5
20 µg

HCST (NM_014266) Human Over-expression Lysate

Human

$628
Cat # LS010870
100 µg

HCST Overview

Facts about Hematopoietic cell signal transducer.

HCST 3D structure. Source: alphafold

Hematopoietic cell signal transducer (HCST)

Transmembrane adapter protein that associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a significant role in triggering cytotoxicity against target cells expressing cell surface ligands like MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological condition such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2.

Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are needed for complete KLRK1-HCST-mediated activation and ultimate killing of target cells.

Gene Information

Human
Gene Name:	HCST
Uniprot:	Q9UBK5
Entrez:	10870

Family

Belongs to:

DAP10 family

Alternative Names

DAP10; DAP10PIK3AP; DKFZP586C1522; HCST; hematopoietic cell signal transducer; KAP10; KAP10DNAX-activation protein 10; kinase assoc pro of ~10kDa; Kinase Assoc Protein; Membrane protein DAP10; phosphoinositide-3-kinase adaptor protein; PIK3AP; Transmembrane adapter protein KAP10