Hcn1 Antibodies

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Hcn1)

Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih).

May mediate responses to sour stimuli. .

Gene Information

Mouse
Gene Name:	Hcn1
Uniprot:	O88704
Entrez:	15165

Family

Belongs to:
potassium channel HCN family

Alternative Names

BCNG1; BCNG-1brain cyclic nucleotide gated channel 1; Brain cyclic nucleotide-gated channel 1; HAC-2; hyperpolarization activated cyclic nucleotide-gated potassium channel 1; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

Molecular Weight

Mass (kDA):
102.432 kDA

Genomic Context

Mouse
Location:	13 D2.3|13 66.34 cM
Sequence:	13;

Tissue Specificity

Predominantly expressed in brain. Highly expressed in apical dendrites of pyramidal neurons in the cortex, in the layer corresponding to the stratum lacunosum-moleculare in the hippocampus and in axons of basket cells in the cerebellum. Expressed in a subset of elongated cells in taste buds.

Diseases

• Epilepsy
• Epilepsy, Temporal Lobe
• Cardiac Arrhythmia
• Nervousness
• Pain
• Absence Epilepsy
• Depressive Disorder
• Channelopathies
• Malnutrition
• Epilepsy, Generalized
• Febrile Convulsions
• Status Epilepticus

• Neuralgia
• Albinism
• Heart Failure
• Bradycardia
• Malignant Neoplasms
• Nerve Damage
• Sclerosis

Pathways

• Localization
• Membrane Hyperpolarization
• Synaptic Transmission
• Cell Cycle
• Glycosylation
• Cardiac Conduction
• Cognition
• Pathogenesis
• Response To Camp
• Aging
• Hypersensitivity
• Anaphase
• Reflex

• Reverse Transcription
• Endocytosis
• Metaphase
• Conjugation
• Cell Death
• Transport
• Cell Migration

PTMs

• Phosphorylation
• Glycosylation

• Acetylation
• Dephosphorylation

• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Hcn1

Boster Bio - Best Uses Of The HCN1 Marker

This article will examine the use of Hcn1 markers in Boster Bio's process for antibody development. This technique makes antibodies using mice and rabbit models. The use of Hcn1 antibodies will enable researchers to investigate the role of this protein in the heart. It is a vital component of the native pacemaker currents of the heart and is involved in the response to sour stimuli.

Boster Bio uses Hcn1 markers

High affinity HCN1 antibodies created by Boster Bio are used in biological assays. These antibodies have been thoroughly validated and cited over the past 25 years. They have been examined by Western Blotting, Immunohistochemistry, and ELISA. Boster Bio antibodies are also able to detect neurones and glial cells. Visit our HCN1 page for more information on the Boster HCN1 anti-body.

Boster Bio, Wuhan, China, has created antibodies against HCN1 to detect the protein in tissues. Monoclonal antibodies against HCN1 gene were used in the creation of the antibodies. Boster Bio uses HCN1 to identify human Astrocytoma. Boster Bio also manufactures HCN1 and GABAB receptor proteins for research. GABAB and HCN1 receptor proteins are proteins that are found in many tissues and organs such as the brain, intestines and bones.

Canine atrial muscles had not been observed to express HCN1 mRNA. It could be because the expression of HCN1 mRNA is extremely low. However significant statistical increases were seen in HCN2 & HCN4 mRNAs of AF patients compared to a sham-group. HCN2 mRNAs and HCN4 were measured by comparing them to 100-bp DNA markers. HCN2 mRNA fragments measured between 143 and 132 bp respectively.

Boster Bio uses mouse and rabbit to develop Hcn1 antibodies.

Antibodies against Hcn1 are widely employed in biological assays, for diagnostic and therapeutic purposes. Monoclonal and polyclonal antibodies can be used, and they are created from a variety of animal sources. Boster Bio uses mouse and rabbit for the development of Hcn1 antibodies. This potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel is believed to contribute to the native pacemaker current in the heart and mediates responses to sour stimuli.