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HABP2 Antibodies
AND HABP2 ELISA kits, HABP2 Proteins
Many biological assays use antibodies to detect HABP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HABP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HABP2 antibodies...
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HABP2 Overview
Facts about Hyaluronan-binding protein 2.
Hyaluronan-binding protein 2 (HABP2)
Cleaves the alpha-chain at multiple sites and the beta- chain between'Lys-53' and'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not lead to the fibrinolysis directly. It does not cleave (trigger ) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro- urokinase) into the active two chain form.
Activates coagulation factor VII (PubMed:8827452, PubMed:10754382, PubMed:11217080). May function as a tumor suppressor negatively regulating cell proliferation and cell migration (PubMed:26222560).
Gene Information
| Human | |
|---|---|
| Gene Name: | HABP2 |
| Uniprot: | Q14520 |
| Entrez: | 3026 |
Family
| Belongs to: |
|---|
| peptidase S1 family |
Alternative Names
EC 3.4.21; EC 3.4.21.-; EC 3.4.21.4; EC 3.4.21.92; Factor seven-activating protease; Factor VII-activating protease; FSAPfactor VII activating protein; HABP; Hepatocyte growth factor activator-like protein; HGFALhyaluronic acid binding protein 2; hyaluronan binding protein 2; hyaluronan-binding protein 2; PHBPplasma hyaluronan binding protein; Plasma hyaluronan-binding protein
Molecular Weight
Mass (kDA):
62.672 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q25.3 |
| Sequence: | 10; NC_000010.11 (113550831..113589602) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Secreted. Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.
Diseases
- Inflammation
- Carotid Stenosis
- Thromboembolism
- Thrombosis
- Stenosis
- Cardiovascular Diseases
- Venous Thrombosis
- Venous Thromboembolism
- Dental Plaque
- Atherosclerosis
- Malignant Neoplasms
- Fibrosis
Pathways
- Coagulation
- Hemostasis
- Fibrinolysis
- Cell Proliferation
- Proteolysis
- Muscle Cell Proliferation
- Regulation Of Coagulation
- Smooth Muscle Cell Proliferation
- Cell Death
- Inflammatory Response
- Chemotaxis
- Blood Coagulation
- Angiogenesis
PTMs
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HABP2
bosterbio.com/bosterbio-gene-info-cards/HABP2
References
PMID: 8827452 by Choi-Miura N.-H., et al. Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator.
PMID: 10754382 by Roemisch J., et al. The FVII activating protease cleaves single-chain plasminogen activators.