This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
Gremlin-1 Antibodies
AND Grem1 ELISA kits, Gremlin-1 Proteins
Many biological assays use antibodies to detect Gremlin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Gremlin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Gremlin-1 antibodies...
Previous: SEPTIN9
Next: Gtf2h2
Grem1 Infographic by Boster Bio
All Grem1 Products
Product
Figures
Specificity
Applications
Price
Grem1 Overview
Facts about Gremlin-1.
Gremlin-1 (Grem1)
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as BMP a antagonist required for early limb outgrowth and patterning in keeping the FGF4-SHH feedback loop (PubMed:12808456, PubMed:15201225). Down-regulates the BMP4 signaling in a dose- dependent manner (PubMed:15133038).
Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity). Acts as inhibitor of monocyte chemotaxis (By similarity).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Grem1 |
| Uniprot: | O70326 |
| Entrez: | 23892 |
Family
| Belongs to: |
|---|
| DAN family |
Alternative Names
Cell proliferation-inducing gene 2 protein; CKTSF1B1gremlin 1, cysteine knot superfamily, homolog; Cysteine knot superfamily 1, BMP antagonist 1gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis); DAN domain family member 2; DAND2; DAND2GREMLIN; Down-regulated in Mos-transformed cells protein; DRM; DRMMGC126660; GREM1; gremlin 1; gremlin 1-like protein; Gremlin; gremlin-1; IHG-2; Increased in high glucose protein 2; increased in high glucose-2; proliferation-inducing gene 2
Molecular Weight
Mass (kDA):
20.71 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 2 E4|2 57.43 cM |
| Sequence: | 2; |
Tissue Specificity
Highly expressed in spleen and to a lesser extent in lung, skeletal muscle and kidney. Expressed only in non- transformed cells or primary fibroblasts in culture but not in established transformed or tumor derived cell lines. Broadly expressed in limb bud mesenchyme but restricted to the distal limb bud mesenchyme and concentrated posteriorly. Expressed in ovary especially in granulosa cells of follicles of type 4.
Diseases
- Malignant Neoplasms
- Kidney Diseases
- Neoplasms
- Diabetic Nephropathy
- Carcinoma
- Fibrosis
- Colorectal Cancer
- Cell Transformation, Neoplastic
- Carcinogenesis
- Tumor Angiogenesis
- Diabetes Mellitus
- Hypertrophy
Pathways
- Limb Development
- Pathogenesis
- Angiogenesis
- Cell Proliferation
- Regeneration
- Kidney Development
- Secretion
- Embryo Development
- Fertilization
- Methylation
- Cell Cycle
- Localization
- Lung Development
PTMs
- Phosphorylation
- Methylation
Research Areas
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Grem1
bosterbio.com/bosterbio-gene-info-cards/Grem1
References
PMID: 9660951 by Hsu D.R., et al. The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities.
PMID: 10965135 by Zhang Q., et al. Cloning of the murine Drm gene (Cktsf1b1) and characterization of its oncogene suppressible promoter.