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GPRC5A Antibodies
AND GPRC5A ELISA kits, GPRC5A Proteins
Many biological assays use antibodies to detect GPRC5A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GPRC5A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GPRC5A antibodies...
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GPRC5A Overview
Facts about Retinoic acid-induced protein 3.
Retinoic acid-induced protein 3 (GPRC5A)
Orphan receptor. Could be involved in regulating differentiation and maintaining homeostasis of epithelial cells.
This retinoic acid-inducible GPCR provide evidence for a potential interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | GPRC5A |
| Uniprot: | Q8NFJ5 |
| Entrez: | 9052 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 3 family |
Alternative Names
G protein-coupled receptor, family C, group 5, member A; GPCR5A; GPRC5A; Orphan G-protein-coupling receptor PEIG-1; RAI3; RAI3G-protein coupled receptor family C group 5 member A; RAIG1; RAIG1RAIG-1; retinoic acid induced 3; retinoic acid responsive; Retinoic acid-induced gene 1 protein; retinoic acid-induced protein 3
Molecular Weight
Mass (kDA):
40.251 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12p13.1 |
| Sequence: | 12; NC_000012.12 (12891562..12917937) |
Tissue Specificity
Expressed at high level in fetal and adult lung tissues but repressed in most human lung cancers (PubMed:9857033, PubMed:18000218). Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Localized in perinuclear vesicles, probably Golgi-associated vesicles.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Lung
- Cell Transformation, Neoplastic
- Lung Neoplasms
- Adenocarcinoma
- Carcinogenesis
- Malignant Neoplasm Of Breast
- Carcinoma
- Mammary Neoplasms
- Malignant Paraganglionic Neoplasm
- Malignant Squamous Cell Neoplasm
- Non-small Cell Lung Carcinoma
Pathways
- Cell Growth
- Cell Proliferation
- Cell Death
- Angiogenesis
- Cell Cycle
- Regulation Of Secretion
- Pathogenesis
- Rna Interference
PTMs
Research Areas
- GPCR
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GPRC5A
bosterbio.com/bosterbio-gene-info-cards/GPRC5A
References
PMID: 8832110 by Cafferata E.G., et al. Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells.
PMID: 9857033 by Cheng Y., et al. Molecular cloning and characterization of a novel retinoic acid- inducible gene that encodes a putative G protein-coupled receptor.