Glypican-1 Antibodies

AND GPC1 ELISA kits, Glypican-1 Proteins

Many biological assays use antibodies to detect Glypican-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Glypican-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Glypican-1 antibodies...

We validate the specificity of these antibodies to Glypican-1 by testing them on tissues known to express GPC1 positively and negatively. Browse below to find the GPC1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GPC1 Infographic by Boster Bio

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Anti-Glypican-1 Antibody

5 Q&As

Human, Mouse, Rat

ELISA, IHC, WB

$629
Cat # A03871
100ug

Anti-GPC1 Mouse Monoclonal Antibody [Clone ID: OTI2H1]

Human, Mouse, Rat

$523
Cat # M03871
100 µl

GPC1 Overview

Facts about Glypican-1.

GPC1 3D structure. Source: alphafold

Glypican-1 (GPC1)

Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity).

May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (through the heparan sulfate side chains) with both kinds of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.

Gene Information

Human
Gene Name:	GPC1
Uniprot:	P35052
Entrez:	2817

Family

Belongs to:

glypican family

Alternative Names

FLJ38078; Glypican 1; glypican proteoglycan 1; glypican; glypican-1; GPC1

Molecular Weight

Mass (kDA):
61.68 kDA

Genomic Context


Human

Location:	2q37.3
Sequence:	2; NC_000002.12 (240435663..240468076)

Subcellular Localizations

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Endosome. S-nitrosylated form recycled in endosomes. Localizes to CAV1-containing vesicles close to the cell surface. Cleavage of heparan sulfate side chains takes place mainly in late endosomes. Associates with both forms of PRNP in lipid rafts. Colocalizes with APP in perinuclear compartments and with CP in intracellular compartments. Associates with fibrillar APP amyloid-beta peptides in lipid rafts in Alzheimer disease brains.; [Secreted glypican-1]: Secreted, extracellular space.

Diseases

Neoplasms
Malignant Neoplasms
Malignant Neoplasm Of Pancreas
Tumor Angiogenesis
Pathologic Neovascularization
Pancreatic Neoplasm
Neoplasm Metastasis
Glioma
Adenocarcinoma
Haploinsufficiency
Inflammation
Polyostotic Fibrous Dysplasia

Carcinoma, Pancreatic Ductal
Nervousness
Brachydactyly
Cell Transformation, Neoplastic
Schizophrenia
Adenoma

Pathways

Angiogenesis
Translation
Cell Proliferation
Brain Development
Cell Cycle
Mitosis
Cell Adhesion
Neurogenesis
Osteoblast Proliferation
Cell Cycle Arrest
Anaphase
Leukocyte Migration
Segmentation

Hemostasis
Sulfation
Response To Anoxia
Response To Stress
G2 Phase
Pollination
Metaphase

PTMs

Cleavage

Phosphorylation

Gpi Anchoring

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GPC1

References

PMID: 2148568 by David G., et al. Molecular cloning of a phosphatidylinositol-anchored membrane heparan sulfate proteoglycan from human lung fibroblasts.

PMID: 12732622 by Mani K., et al. Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate.