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- Table of Contents
, No Gclids
GDF5 Antibodies
AND GDF5 ELISA kits, GDF5 Proteins
Many biological assays use antibodies to detect GDF5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GDF5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GDF5 antibodies...
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GDF5 Infographic by Boster Bio
All GDF5 Products
Product
Figures
Specificity
Applications
Price
Mouse
ELISA
$750
Cat # EK1505
96 wells/kit, with removable strips.
Cat # EK1505
96 wells/kit, with removable strips.
Rat GDF5/Bmp 14 ELISA Kit PicoKine®
1 Citations 8 Q&As
Rat
ELISA
$750
Cat # EK1504
96 wells/kit, with removable strips.
Cat # EK1504
96 wells/kit, with removable strips.
Bovine GDF5 ELISA Kit PicoKine®
10 Q&As
Bovine
ELISA
$750
Cat # EK1504-BV
96 wells/kit, with removable strips.
Cat # EK1504-BV
96 wells/kit, with removable strips.
Pig
ELISA
$750
Cat # EK1504-PO
96 wells/kit, with removable strips.
Cat # EK1504-PO
96 wells/kit, with removable strips.
Hamster
ELISA
$750
Cat # EK1504-HA
96 wells/kit, with removable strips.
Cat # EK1504-HA
96 wells/kit, with removable strips.
Chicken
ELISA
$750
Cat # EK1504-CH
96 wells/kit, with removable strips.
Cat # EK1504-CH
96 wells/kit, with removable strips.
Equine
ELISA
$750
Cat # EK1504-EQ
96 wells/kit, with removable strips.
Cat # EK1504-EQ
96 wells/kit, with removable strips.
Rabbit
ELISA
$750
Cat # EK1504-RB
96 wells/kit, with removable strips.
Cat # EK1504-RB
96 wells/kit, with removable strips.
Monkey
ELISA
$750
Cat # EK1504-PR
96 wells/kit, with removable strips.
Cat # EK1504-PR
96 wells/kit, with removable strips.
Human
Cell Culture
$77
Cat # PROTP43026-4
5ug,20ug,100ug
Cat # PROTP43026-4
5ug,20ug,100ug
GDF5 Overview
Facts about Growth/differentiation factor 5.
Growth/differentiation factor 5 (GDF5)
Growth factor involved in cartilage and bone formation. During cartilage development regulates differentiation of chondrogenic tissue via two pathways.
Primarily, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complicated phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Second, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273).
Gene Information
| Human | |
|---|---|
| Gene Name: | GDF5 |
| Uniprot: | P43026 |
| Entrez: | 8200 |
Family
| Belongs to: |
|---|
| TGF-beta family |
Alternative Names
BMP14; BMP-14; Cartilage-derived morphogenetic protein 1; cartilage-derived morphogenetic protein-1; CDMP-1; CDMP1LAP4; GDF5; GDF-5; growth differentiation factor 5; growth/differentiation factor 5; OS5; radotermin; SYNS2
Molecular Weight
Mass (kDA):
55.411 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q11.22 |
| Sequence: | 20; NC_000020.11 (35433347..35454749, complement) |
Tissue Specificity
Predominantly expressed in long bones during embryonic development. Expressed in monocytes (at protein level).
Subcellular Localizations
Secreted. Cell membrane.
Diseases
- Degenerative Polyarthritis
- Osteoarthritis, Knee
- Brachydactyly
- Arthritis
- Limb Deformities, Congenital
- Hypertrophy
- Syndactyly
- Intervertebral Disc Degeneration
- Parkinson Disease
- Tissue Adhesions
- Osteoarthritis Of Hip
- Arthropathy
Interacting Proteins
- BMPR1A
- BMPR1B
- BMPR2
- TNFAIP6
Pathways
- Regeneration
- Cell Proliferation
- Pathogenesis
- Chondrocyte Differentiation
- Ossification
- Limb Development
- Endochondral Ossification
- Angiogenesis
- Cell Differentiation
- Segmentation
- Localization
- Cell Death
- Secretion
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GDF5
bosterbio.com/bosterbio-gene-info-cards/GDF5
References
PMID: 7980526 by Hoetten G., et al. Cloning and expression of recombinant human growth/differentiation factor 5.
PMID: 7961761 by Chang S., et al. Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development.
1 Publications of Boster GDF5 Antibodies & ELISA Kits
- PubMed ID: -, Iwan,A.,Moskalewski,S.,& Hyc,A.(2021).Growth factor profile in calcified cartila...
*More publications can be found for each product on its corresponding product page