GUCY2C Antibodies

AND GUCY2C ELISA kits, GUCY2C Proteins

Many biological assays use antibodies to detect GUCY2C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GUCY2C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GUCY2C antibodies...

We validate the specificity of these antibodies to GUCY2C by testing them on tissues known to express GUCY2C positively and negatively. Browse below to find the GUCY2C antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GUCY2C Infographic by Boster Bio

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GUCY2C (NM_004963) Human Over-expression Lysate

Human

$960
Cat # LS002984
100 µg

GUCY2C Overview

Facts about Heat-stable enterotoxin receptor.

GUCY2C 3D structure. Source: alphafold

Heat-stable enterotoxin receptor (GUCY2C)

Receptor for the E.coli heat-stable enterotoxin (E.

coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin.

Gene Information

Human
Gene Name:	GUCY2C
Uniprot:	P25092
Entrez:	2984

Family

Belongs to:

adenylyl cyclase class-4/guanylyl cyclase family

Alternative Names

DIAR6; EC 4.6.1; GCC; GC-C; guanylate cyclase 2C (heat stable enterotoxin receptor); Guanylate Cyclase C; Guanylyl Cyclase C; GUC2C; GUC2CEC 4.6.1.2; GUCY2C; heat-stable enterotoxin receptor; hSTAR; Intestinal guanylate cyclase; MUCIL; STA Receptor; StAR; STARSTA receptor

Molecular Weight

Mass (kDA):
123.403 kDA

Genomic Context


Human

Location:	12p12.3
Sequence:	12; NC_000012.12 (14612632..14696625, complement)

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. The 145 kDa plasma membrane form of GC-C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form.

Diseases

Malignant Neoplasms
Neoplasms
Colorectal Neoplasms
Neoplasm Metastasis
Colorectal Cancer
Lymphatic Metastasis
Cystic Fibrosis
Metastatic Malignant Neoplasm To The Lymph Node
Malignant Tumor Of Colon
Fibrosis
Diarrhea
Neoplasm Recurrence, Local
Inflammatory Bowel Diseases

Constipation
Intestinal Diseases
Colitis
Cell Transformation, Neoplastic
Intestinal Neoplasms
Obesity
Inflammation

Pathways

Secretion
Transport
Cell Proliferation
Natriuresis
Glomerular Filtration
Secretory Pathway
Cytolysis
Dna Methylation
Oxidative Phosphorylation
Localization
Diuresis
Methylation
Telomere Organization

Cytokine Production
Water Transport
Water Homeostasis
Cellular Localization
Mesoderm Development
Feeding Behavior
Glycolysis

PTMs

Phosphorylation

Methylation

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GUCY2C

References

PMID: 1718270 by Singh S., et al. Isolation and expression of a guanylate cyclase-coupled heat stable enterotoxin receptor cDNA from a human colonic cell line.

PMID: 1680854 by de Sauvage F.J., et al. Primary structure and functional expression of the human receptor for Escherichia coli heat-stable enterotoxin.