GUCA2B Antibodies

AND GUCA2B ELISA kits, GUCA2B Proteins

Many biological assays use antibodies to detect GUCA2B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GUCA2B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GUCA2B antibodies...

We validate the specificity of these antibodies to GUCA2B by testing them on tissues known to express GUCA2B positively and negatively. Browse below to find the GUCA2B antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GUCA2B Infographic by Boster Bio

All GUCA2B Products

Product

Figures

Specificity

Applications

Price

GUCA2B Prouroguanylin Human Recombinant Protein

Human

$250
Cat # PROTQ16661
2ug, 10ug, 1mg

Anti-Guanylate cyclase activator 2B GUCA2B Antibody

Mouse

$405
Cat # A09489
100ul

Anti-GUC2B GUCA2B Antibody

Human

ELISA, WB

$380
Cat # A09489-1
100ul

Uroguanylin (GUCA2B) (NM_007102) Human Over-expression Lysate

Human

$628
Cat # LS002981
100 µg

GUCA2B Overview

Facts about Guanylate cyclase activator 2B.

GUCA2B 3D structure. Source: alphafold

Guanylate cyclase activator 2B (GUCA2B)

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the exact same receptor binding region as the heat-stable enterotoxins.

May be a potent physiological regulator of intestinal fluid and electrolyte transport. Might be an autocrine/paracrine regulator of intestinal salt and water transport.

Gene Information

Human
Gene Name:	GUCA2B
Uniprot:	Q16661
Entrez:	2981

Family

Belongs to:

guanylin family

Alternative Names

GCAP-II; guanylate cyclase activator 2B (uroguanylin); guanylate cyclase activator 2B; UGN; uroguanylin

Molecular Weight

Mass (kDA):
12.069 kDA

Genomic Context


Human

Location:	1p34.2
Sequence:	1; NC_000001.11 (42153410..42155820)

Tissue Specificity

Stomach and intestine.

Subcellular Localizations

Secreted.

Diseases

Pseudopregnancy
Essential Hypertension
Endometrial Polyp
Deciduoma
Hypertensive Disease
Colonic Diseases
Malignant Neoplasms
Neoplasms
Colorectal Neoplasms

Inflammation
Colorectal Cancer
Colitis

Pathways

Transport
Methylation
Decidualization
Cytokine Production
Water Transport
Dna Methylation
Localization

Secretion

PTMs

Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GUCA2B

References

PMID: 8605041 by Miyazato M., et al. Cloning and characterization of a cDNA encoding a precursor for human uroguanylin.

PMID: 8519795 by Hill O., et al. A new human guanylate cyclase-activating peptide (GCAP-II, uroguanylin): precursor cDNA and colonic expression.