GUCA1B Antibodies

AND GUCA1B ELISA kits, GUCA1B Proteins

Many biological assays use antibodies to detect GUCA1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GUCA1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GUCA1B antibodies...

We validate the specificity of these antibodies to GUCA1B by testing them on tissues known to express GUCA1B positively and negatively. Browse below to find the GUCA1B antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GUCA1B Infographic by Boster Bio

All GUCA1B Products

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GCAP2 (GUCA1B) (NM_002098) Human Over-expression Lysate

Human

$628
Cat # LS002979
100 µg

GUCA1B Overview

Facts about Guanylyl cyclase-activating protein 2.

GUCA1B 3D structure. Source: alphafold

Guanylyl cyclase-activating protein 2 (GUCA1B)

Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is reduced, and GC1 and GC2 when free calcium ions concentration is raised. This Ca(2+)-sensitive regulation of GC is an integral event in recovery of the dark state of rod photoreceptors following light exposure.

Gene Information

Human
Gene Name:	GUCA1B
Uniprot:	Q9UMX6
Entrez:	2979

Family

Belongs to:

No superfamily

Alternative Names

DKFZp686E1183; GCAP 2; GCAP2guanylate cyclase-activating protein, photoreceptor 2; guanylate cyclase activator 1B (retina); Guanylate cyclase activator 1B; guanylyl cyclase-activating protein 2; GUCA2; RP48

Molecular Weight

Mass (kDA):
23.42 kDA

Genomic Context


Human

Location:	6p21.1
Sequence:	6; NC_000006.12 (42183284..42194956, complement)

Tissue Specificity

Retina. Cones and rod.

Subcellular Localizations

Cell projection, cilium, photoreceptor outer segment. Cell membrane; Lipid-anchor. Subcellular location is not affected by light or dark conditions.

Diseases

Dystrophy
Retinitis Pigmentosa
Retinal Diseases
Retinal Degeneration
Amaurosis
Leber Congenital Amaurosis
Retinal Dystrophies
Age Related Macular Degeneration
Abnormal Degeneration
Cystic Fibrosis

Malignant Tumor Of Colon
Carcinoma
Fibrosis
Flasher - Visual Manifestation
Photophobia

Pathways

Phototransduction
Localization
Proteolysis
Secretion
Translation
Response To Light Stimulus
Cell Death

Pathogenesis

PTMs

Phosphorylation

Dephosphorylation

Myristoylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GUCA1B

References

PMID: 9119368 by Surguchov A., et al. The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1).

PMID: 10507726 by Payne A.M., et al. Genetic analysis of the guanylate cyclase activator 1B (GUCA1B) gene in patients with autosomal dominant retinal dystrophies.